Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1996-8-8
|
pubmed:abstractText |
Many authors currently recommend infusing the adult dose (1 g) of pralidoxime over a 15-30 minute period. When administered in this manner, computer simulations predict that plasma pralidoxime concentrations will fall below 4 mg/L as early as one and one half hours after administration. The objective of this study was to assess whether a loading dose followed by a continuous infusion would maintain therapeutic levels longer than the traditional short infusion regimen of pralidoxime if the same total dose was administered.
|
pubmed:commentsCorrections | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0731-3810
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
34
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
289-95
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8667466-Adult,
pubmed-meshheading:8667466-Antidotes,
pubmed-meshheading:8667466-Blood Pressure,
pubmed-meshheading:8667466-Cross-Over Studies,
pubmed-meshheading:8667466-Drug Administration Schedule,
pubmed-meshheading:8667466-Female,
pubmed-meshheading:8667466-Humans,
pubmed-meshheading:8667466-Infusions, Intravenous,
pubmed-meshheading:8667466-Male,
pubmed-meshheading:8667466-Middle Aged,
pubmed-meshheading:8667466-Pralidoxime Compounds,
pubmed-meshheading:8667466-Reference Values
|
pubmed:year |
1996
|
pubmed:articleTitle |
Pharmacokinetics following a loading plus a continuous infusion of pralidoxime compared with the traditional short infusion regimen in human volunteers.
|
pubmed:affiliation |
University Hospital, State University of New York, Health Science Center at Syracuse 13210, USA.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|