Linked Life Data

8666938

Source:http://linkedlifedata.com/resource/pubmed/id/8666938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-8-5
pubmed:abstractText
Natural killer (NK) cells that express the NKB1 receptor are inhibited from killing target cells that possess human histocompatibility leukocyte antigen (HLA) B molecules bearing the Bw4 serological epitope. To investigate whether NKB1 expression is affected by HLA type, peripheral blood lymphocytes of 203 HLA-typed donors were examined. Most donors had a single population of NKB1+ cells, but some had two populations expressing different cell surface levels of NKB1, and others had no detectable NKB1+ cells. Among the donors expressing NKB1, both the relative abundance of NKB1+ NK cells and their level of cell surface expression varied substantially. The percentage of NKB1+ NK cells ranged from 0 to >75% (mean 14.7%), and the mean fluorescence of the positive population varied over three orders of magnitude. For each donor, the small percentage of T cells expressing NKB1 (usually <2%), had a pattern of expression mirroring that of the NK cells. NKB1 expression by NK and T cells remained stable over the 2-yr period that five donors were tested. Patterns of NKB1 expression were not associated with Bw4 or Bw6 serotype of the donor or with the presence of any individual HLA-A or -B antigens. Cells expressing NKB1 are often found in donors who do not possess an appropriate class I ligand, and can be absent in those who express Bw4+ HLA-B antigens. Family studies further suggested that the phenotype of NKB1 expression is inherited but not HLA linked. Whereas identical twins show matching patterns of NKB1 expression, HLA-identical siblings can differ in NKB1 expression, and conversely, HLA-disparate siblings can be similar. Thus NKB1 expression phenotypes are tightly regulated and extremely heterogeneous, but not correlated with HLA type.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-1614533, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-2201309, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-2431040, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-2683611, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-2707298, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-2784569, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-3257565, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-3951539, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-6086760, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-6225799, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7477341, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7532677, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7561113, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7630404, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7650366, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7716543, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7749980, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7878033, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-7931060, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8027540, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8046332, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8046342, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8077656, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8113669, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8315379, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8476574, http://linkedlifedata.com/resource/pubmed/commentcorrection/8666938-8777725
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
183
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1817-27
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype.
pubmed:affiliation
Department of Microbiology, Stanford University, California 94305, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't
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