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rdf:type |
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lifeskim:mentions |
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0175631,
umls-concept:C0243127,
umls-concept:C0443331,
umls-concept:C1167395,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1880022,
umls-concept:C2698600,
umls-concept:C2827662
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pubmed:issue |
4
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pubmed:dateCreated |
1996-8-5
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pubmed:abstractText |
The cellular basis of T cell memory is a controversial issue and progress has been hampered by the inability to induce and to trace long-term memory T cells specific for a defined antigen in vivo. By using the murine model of lymphocytic choriomeningitis virus (LCMV) infection and an adoptive transfer system with CD8+ T cells from transgenic mice expressing an LCMV-specific T cell receptor, a population of authentic memory T cells specific for LCMV was generated and analyzed in vivo. The transgenic T cells that have expanded (1,000-fold) and then decreased (10-fold) in LCMV-infected C57BL/6 recipient mice exhibited the following characteristics: they were (a) of larger average cell size than their naive counterparts but smaller than day 8 effector cells; (b) heterogeneous with respect to expression of cell surface "memory" markers; and (c) directly cytolytic when isolated from recipient spleens. The time-dependent proliferative activity of these LCMV-specific memory T cells was analyzed in the recipients by bromodeoxyuridine labeling experiments in vivo. The experiments revealed that LCMV-specific CD8+ memory T cells can persist in LCMV-immune mice for extended periods of time (>2 mo) in the absence of cell division; the memory population as a whole survived beyond 11 mo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1388189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1402673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1436108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1439825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1500720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1555235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1834764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1898663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1939506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1970350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-1978253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2388695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2526179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2567673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2653379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2886344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2894392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2972769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-2978373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-3108367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-3877779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-4133331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-6239901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-6806380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7505109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7514632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7516038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7516039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7529281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7535181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7535476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7537304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7538535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7600283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7600301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7678116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7889419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7908301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-7910137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-8100135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-8145034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-8195718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-8270876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-8344359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8666895-8512036
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1367-75
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8666895-Animals,
pubmed-meshheading:8666895-Mice,
pubmed-meshheading:8666895-Spleen,
pubmed-meshheading:8666895-Peptide Fragments,
pubmed-meshheading:8666895-Lymphocytic Choriomeningitis,
pubmed-meshheading:8666895-Viral Proteins,
pubmed-meshheading:8666895-Amino Acid Sequence,
pubmed-meshheading:8666895-Lymphocyte Activation,
pubmed-meshheading:8666895-Molecular Sequence Data,
pubmed-meshheading:8666895-Immunologic Memory,
pubmed-meshheading:8666895-Mice, Inbred C57BL,
pubmed-meshheading:8666895-Cytotoxicity, Immunologic,
pubmed-meshheading:8666895-Biological Markers,
pubmed-meshheading:8666895-Receptors, Antigen, T-Cell,
pubmed-meshheading:8666895-Flow Cytometry
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