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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-8-7
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pubmed:databankReference |
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pubmed:abstractText |
A novel human chromosome locus-specific repetitive sequence was identified and characterized using arbitrary PCR. The repeat monomer consensus sequence is 100 bp long, and there are a minimum of 140 to 160 copies of the repetitive sequence per haploid human genome. The repetitive sequence is highly clustered on 20q12 within a 200- to 400-kb region. The highly polymorphic repeat array is inherited in a stable Mendelian fashion. Hybridization analysis revealed detectable conservation of the repeated element only among hominoids and Old World monkeys, where repeat arrangements are also polymorphic.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-402
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8666387-Animals,
pubmed-meshheading:8666387-Base Sequence,
pubmed-meshheading:8666387-Blotting, Southern,
pubmed-meshheading:8666387-Cercopithecidae,
pubmed-meshheading:8666387-Chromosome Mapping,
pubmed-meshheading:8666387-Consensus Sequence,
pubmed-meshheading:8666387-DNA,
pubmed-meshheading:8666387-Female,
pubmed-meshheading:8666387-Genome, Human,
pubmed-meshheading:8666387-Hominidae,
pubmed-meshheading:8666387-Humans,
pubmed-meshheading:8666387-Hybrid Cells,
pubmed-meshheading:8666387-Male,
pubmed-meshheading:8666387-Molecular Sequence Data,
pubmed-meshheading:8666387-Pedigree,
pubmed-meshheading:8666387-Polymerase Chain Reaction,
pubmed-meshheading:8666387-Polymorphism, Genetic,
pubmed-meshheading:8666387-Random Amplified Polymorphic DNA Technique,
pubmed-meshheading:8666387-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8666387-Sequence Homology, Nucleic Acid
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pubmed:year |
1995
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pubmed:articleTitle |
Human genomic characterization of a novel locus-specific repetitive sequence.
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pubmed:affiliation |
BIOS Laboratories, Inc., New Haven, Connecticut 06511, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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