Linked Life Data

8664811

Source:http://linkedlifedata.com/resource/pubmed/id/8664811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-8-5
pubmed:abstractText
A randomized chemoprevention trial on precancerous lesions of the stomach is being conducted in Tachira State, Venezuela. The aims of the study are to evaluate the efficacy of vitamin supplementation in preventing the progression rate of precancerous lesions. Here we report on the pilot phase of the study in which two antioxidant preparations were evaluated on their ability to raise antioxidant levels in plasma and in gastric juice. The study aimed also to determine the antibiotic sensitivity profiles of Helicobacter pylori isolates prevalent in the area. Forty-three subjects with precancerous lesions (chronic gastritis, chronic atrophic gastritis, intestinal metaplasia and dysplasia) of the stomach were randomized to one of two antioxidant treatments. Treatment 1 (250 mg of standard vitamin C, 200 mg of vitamin E and 6 mg of beta-carotene three times a day) or treatment 2 (150 mg of standard vitamin C, 500 mg of slow release vitamin C, 75 mg of vitamin E and 15 mg of beta-carotene once a day) for 7 days. Blood levels of total vitamin C, beta-carotene and alpha-tocopherol and gastric juice levels of ascorbic acid and total vitamin C were measured before and after treatment on day 8. Both treatments increased the plasma levels of total vitamin C, beta-carotene and alpha-tocopherol/cholesterol but not those of ascorbic acid or total vitamin C in gastric juice. Treatment 1 was the best choice and resulted in a greater increase in the plasma levels of beta-carotene and alpha-tocopherol. H. pylori was cultured from 90% of the gastric biopsies; 35 isolates were identified which were highly resistant to metronidazole, a front-line antibiotic recommended against H. pylori in other settings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-8278
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8664811-Adult, pubmed-meshheading:8664811-Aged, pubmed-meshheading:8664811-Antioxidants, pubmed-meshheading:8664811-Ascorbic Acid, pubmed-meshheading:8664811-Carotenoids, pubmed-meshheading:8664811-Chemoprevention, pubmed-meshheading:8664811-Chronic Disease, pubmed-meshheading:8664811-Disease Progression, pubmed-meshheading:8664811-Female, pubmed-meshheading:8664811-Gastric Juice, pubmed-meshheading:8664811-Gastritis, pubmed-meshheading:8664811-Gastritis, Atrophic, pubmed-meshheading:8664811-Helicobacter Infections, pubmed-meshheading:8664811-Helicobacter pylori, pubmed-meshheading:8664811-Humans, pubmed-meshheading:8664811-Male, pubmed-meshheading:8664811-Metaplasia, pubmed-meshheading:8664811-Middle Aged, pubmed-meshheading:8664811-Pilot Projects, pubmed-meshheading:8664811-Precancerous Conditions, pubmed-meshheading:8664811-Stomach Neoplasms, pubmed-meshheading:8664811-Venezuela, pubmed-meshheading:8664811-Vitamin E, pubmed-meshheading:8664811-Vitamins, pubmed-meshheading:8664811-beta Carotene
pubmed:year
1996
pubmed:articleTitle
Antioxidants, Helicobacter pylori and stomach cancer in Venezuela.
pubmed:affiliation
Servei d'Epidemiologia i Registre del Cancer, Institut Català d'Oncologia Hospital Duran i Reynals, Barcelona, Spain.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't