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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1996-8-8
|
pubmed:abstractText |
Amplification and overexpression of the C-ERBB2 oncogene have been associated with a poor prognosis and a lower response to chemotherapy in human breast cancer. In this study, plasma c-erbB2 concentrations were determined using an enzyme immunoassay in patients with breast cancer. The links between c-erbB2 concentration and tumoral response to chemotherapy were established. The patients with a c-erbB2 concentration higher than the cut-off value (27 U/ml) were considered as c-erbB2+. Ten of the 33 metastatic breast cancers were c-erbB2+. No statistically significant difference in response to chemotherapy was noted between c-erbB2+ and c-erbB2- patients (4/10 objective responses versus 10/23). Variations in c-erbB2 concentrations during treatment were not related to response to treatment.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0959-8049
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
32A
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
231-4
|
pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8664033-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8664033-Breast Neoplasms,
pubmed-meshheading:8664033-Disease Progression,
pubmed-meshheading:8664033-Female,
pubmed-meshheading:8664033-Humans,
pubmed-meshheading:8664033-Neoplasm Metastasis,
pubmed-meshheading:8664033-Neoplasm Proteins,
pubmed-meshheading:8664033-Receptor, erbB-2,
pubmed-meshheading:8664033-Retrospective Studies,
pubmed-meshheading:8664033-Treatment Outcome,
pubmed-meshheading:8664033-Tumor Markers, Biological
|
pubmed:year |
1996
|
pubmed:articleTitle |
Plasma c-erbB2 concentrations in relation to chemotherapy in breast cancer patients.
|
pubmed:affiliation |
Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|