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| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:8662280 | lifeskim:mentions | umls-concept:C0699493 | lld:lifeskim |
| pubmed-article:8662280 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8662280 | pubmed:dateCreated | 1997-4-8 | lld:pubmed |
| pubmed-article:8662280 | pubmed:abstractText | 45Ca2+ flux and single channel measurements have related that the Ca2+ release channel/ryanodine receptor complex of striated muscle is regulated by micromolar cytoplasmic Ca2+. The effect of luminal Ca2+, however, remains controversial. In the experiments presented here, we reconstituted the isolated Ca2+ release channel of rabbit skeletal muscle sarcoplasmic reticulum into planar lipid bilayers in the presence of symmetrical K+ solutions. Using K+ as the charge carrier, we were able to examine the effect of changes in luminal calcium in the micro- to millimolar range. In the presence of activating cytoplasmic Ca2+, the release channel was activated and inactivated in a concentration-dependent manner by luminal Ca2+. Since increasing cytoplasmic EGTA concentrations shifted the dependence of channel open probability on luminal Ca2+ to higher Ca2+ concentrations, it is suggested that luminal Ca2+ exerts ist regulating effect by acting on Ca2+ binding sites accessible from the cytoplasmic side of the channel. | lld:pubmed |
| pubmed-article:8662280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8662280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8662280 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8662280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8662280 | pubmed:month | May | lld:pubmed |
| pubmed-article:8662280 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:8662280 | pubmed:author | pubmed-author:Lehmann-HornF... | lld:pubmed |
| pubmed-article:8662280 | pubmed:author | pubmed-author:Herrmann-Fran... | lld:pubmed |
| pubmed-article:8662280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8662280 | pubmed:volume | 432 | lld:pubmed |
| pubmed-article:8662280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8662280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8662280 | pubmed:pagination | 155-7 | lld:pubmed |
| pubmed-article:8662280 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8662280 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8662280 | pubmed:articleTitle | Regulation of the purified Ca2+ release channel/ryanodine receptor complex of skeletal muscle sarcoplasmic reticulum by luminal calcium. | lld:pubmed |
| pubmed-article:8662280 | pubmed:affiliation | Department of Applied Physiology, University of Ulm, D-89069 Ulm, Germany. | lld:pubmed |
| pubmed-article:8662280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8662280 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8662280 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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