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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-8-8
|
| pubmed:abstractText |
Several recent studies have demonstrated the potential for improving myocardial perfusion by the continuous administration of angiogenic growth factors. Studies in our laboratory have shown that a single intraarterial or intravenous bolus of the endothelial cell specific mitogen vascular endothelial growth factor (VEGF) can significantly improve perfusion in a rabbit ischemic limb model. To test the efficacy of this therapeutic approach in chronic myocardial ischemia, 18 Yorkshire pigs underwent a left thoracotomy followed by placement of an ameroid constrictor around the proximal circumflex coronary artery. Gradual occlusion of the artery (26 +/- 4 days) was accompanied by identifiable hypokinesis of the posterolateral wall of the left ventricle (2D echo). Thirty days postoperatively, rhVEGF(165) (2 mg; n = 8) or saline (n = 10) was administered directly into the left coronary ostium. Postadenosine myocardial perfusion studies using colored microspheres 30 days later demonstrated superior blood flow in the ischemic zone of the VEGF-treated hearts (ischemic/normal ratio 1.09 vs 0.97, P < 0.05) compared with those receiving saline injection. Four of eight VEGF-treated animals succumbed, however, to severe hypotension following VEGF administration. Therefore 500 micrograms of VEGF were administered intracoronary to five normal pigs. A significant drop in mean arterial pressure (-44.4 +/- 3.2%, P < 0.05 vs baseline) and peripheral resistance (-13.2 +/- 4.5%, P < 0.05 vs baseline) was accompanied by increased heart rate. IV administration of N(omega)-nitro-L-arginine (L-NNA), an EDRF inhibitor, restored blood pressure to baseline. We conclude that a single intracoronary bolus of VEGF is capable of significantly augmenting flow to collateral-dependent ischemic myocardium. The associated hypotension appears to be EDRF-mediated. Further studies are needed to define the best dose and route of administration of VEGF for the treatment of coronary insufficiency.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-82
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8661176-Adenosine,
pubmed-meshheading:8661176-Animals,
pubmed-meshheading:8661176-Arginine,
pubmed-meshheading:8661176-Blood Pressure,
pubmed-meshheading:8661176-Coronary Circulation,
pubmed-meshheading:8661176-Coronary Vessels,
pubmed-meshheading:8661176-Echocardiography,
pubmed-meshheading:8661176-Endothelial Growth Factors,
pubmed-meshheading:8661176-Enzyme Inhibitors,
pubmed-meshheading:8661176-Humans,
pubmed-meshheading:8661176-Hypotension,
pubmed-meshheading:8661176-Lymphokines,
pubmed-meshheading:8661176-Microspheres,
pubmed-meshheading:8661176-Myocardial Ischemia,
pubmed-meshheading:8661176-Myocardial Reperfusion,
pubmed-meshheading:8661176-Nitric Oxide,
pubmed-meshheading:8661176-Nitric Oxide Synthase,
pubmed-meshheading:8661176-Nitroarginine,
pubmed-meshheading:8661176-Rabbits,
pubmed-meshheading:8661176-Recombinant Proteins,
pubmed-meshheading:8661176-Swine,
pubmed-meshheading:8661176-Vascular Endothelial Growth Factor A,
pubmed-meshheading:8661176-Vascular Endothelial Growth Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts.
|
| pubmed:affiliation |
Division of Cardiothoracic Surgery, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.
|
| pubmed:publicationType |
Journal Article
|