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rdf:type |
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lifeskim:mentions |
umls-concept:C0008643,
umls-concept:C0008667,
umls-concept:C0013879,
umls-concept:C0017337,
umls-concept:C0085177,
umls-concept:C0475264,
umls-concept:C0599777,
umls-concept:C0679058,
umls-concept:C1415638,
umls-concept:C1547699,
umls-concept:C2700640
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pubmed:issue |
2
|
|
pubmed:dateCreated |
1997-2-11
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|
pubmed:abstractText |
Messenger RNAs encoding many oncoproteins and cytokines are relatively unstable. Their instability, which ensures appropriate levels and timing of expression, is controlled in part by proteins that bind to A+U-rich instability elements (AREs) present in the 3'-untranslated regions of the mRNAs. cDNAs encoding the AUF1 family of ARE-binding proteins were cloned from human and murine cDNA libraries. In the present study monochromosomal somatic cell hybrids were used to localize two AUF1 loci to human chromosomes 4 and X. In situ hybridization analyses using P1 clones as probes identified the 4q21.1-q21.2 and Xq12 regions as the locations of the AUF1 genes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Jun
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pubmed:issn |
0888-7543
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
34
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
219-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8661052-Animals,
pubmed-meshheading:8661052-Base Composition,
pubmed-meshheading:8661052-Binding Sites,
pubmed-meshheading:8661052-Chromosome Mapping,
pubmed-meshheading:8661052-Chromosomes, Human, Pair 4,
pubmed-meshheading:8661052-Cloning, Molecular,
pubmed-meshheading:8661052-DNA, Complementary,
pubmed-meshheading:8661052-Gene Library,
pubmed-meshheading:8661052-Heterogeneous-Nuclear Ribonucleoprotein D,
pubmed-meshheading:8661052-Humans,
pubmed-meshheading:8661052-Hybrid Cells,
pubmed-meshheading:8661052-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8661052-Mice,
pubmed-meshheading:8661052-RNA, Messenger,
pubmed-meshheading:8661052-RNA-Binding Proteins,
pubmed-meshheading:8661052-Recombinant Proteins,
pubmed-meshheading:8661052-X Chromosome
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pubmed:year |
1996
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pubmed:articleTitle |
Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X.
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pubmed:affiliation |
Department of Microbiology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina, 27157, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
