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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-8-27
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pubmed:abstractText |
Growth cones and neurites of chicken dorsal root ganglia neurons cultured on laminin, Ng-CAM, or axonin-1 exhibit substratum-dependent morphology and growth patterns which are accompanied by distinctive distributions of axonin-1 and Ng-CAM in the growth cone membrane. On either Ng-CAM or axonin-1 substratum, both Ng-CAM and axonin-1 were depleted from some areas of the apical growth cone membrane. In contrast, on laminin, both axonin-1 and Ng-CAM remained randomly distributed. Removal of axonin-1 from growth cones resulted in a blockage of neurite outgrowth on both Ng-CAM and axonin-1 substrata, indicating that in these neurons axonin-1 cooperates with Ng-CAM in the activation of axon growth. Based on these results possible molecular models for cooperation between axonin-1 and Ng-CAM on the growth cone are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-29
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8660873-Animals,
pubmed-meshheading:8660873-Antibodies, Blocking,
pubmed-meshheading:8660873-Axons,
pubmed-meshheading:8660873-Cell Adhesion Molecules, Neuron-Glia,
pubmed-meshheading:8660873-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:8660873-Cells, Cultured,
pubmed-meshheading:8660873-Chick Embryo,
pubmed-meshheading:8660873-Contactin 2,
pubmed-meshheading:8660873-Fluorescent Antibody Technique,
pubmed-meshheading:8660873-Ganglia, Spinal,
pubmed-meshheading:8660873-Immunohistochemistry,
pubmed-meshheading:8660873-Microscopy, Electron, Scanning,
pubmed-meshheading:8660873-Microscopy, Immunoelectron,
pubmed-meshheading:8660873-Neurites
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pubmed:year |
1996
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pubmed:articleTitle |
Clustering and functional cooperation of Ng-CAM and axonin-1 in the substratum-contact area of growth cones.
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pubmed:affiliation |
Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, Zürich, CH-8057, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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