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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-8-6
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pubmed:databankReference |
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pubmed:abstractText |
There is increasing interest in the role of RNA-binding proteins during neural development. Drosophila Musashi is one of the neural RNA-binding proteins essential for neural development and required for asymmetric cell divisions in the Drosophila adult sensory organ development. Here, a novel mammalian neural RNA-binding protein, mouse-Musashi-1, was identified based on the homology to Drosophila Musashi and Xenopus NRP-1. In the developing CNS, mouse-Musashi-1 protein was highly enriched in the CNS stem cell. Single-cell culture experiments indicated that mouse-Musashi-1 expression is associated with neural precursor cells that are capable of generating neurons and glia. In contrast, in fully differentiated neuronal and glial cells mouse-Musashi-1 expression is lost. This expression pattern of mouse-Musashi-1 is complementary to that of another mammalian neural RNA-binding protein, Hu (a mammalian homologue of a Drosophila neuronal RNA-binding protein Elav), that is expressed in postmitotic neurons within the CNS. In vitro studies indicated that mouse-Musashi-1 possesses binding preferences on poly(G) RNA homopolymer, whereas Hu is known to preferentially bind to short A/U-rich regions in RNA. Based on their differential expression patterns and distinct preferential target RNA sequences, we believe that the mouse-Musashi-1 and Hu proteins may play distinct roles in neurogenesis, either through sequential regulatory mechanisms or differential sorting of mRNA populations during asymmetric division of neural precursor cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intermediate Filament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Msi1h protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/musashi protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/nestin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0012-1606
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pubmed:author |
pubmed-author:ArugaJJ,
pubmed-author:HamaguchiKK,
pubmed-author:ImaiTT,
pubmed-author:KuriharaYY,
pubmed-author:MikoshibaKK,
pubmed-author:MiyataTT,
pubmed-author:NagataTT,
pubmed-author:NakajimaKK,
pubmed-author:OgawaMM,
pubmed-author:OkabeMM,
pubmed-author:OkanoHH,
pubmed-author:SakakibaraSS,
pubmed-author:UesugiSS,
pubmed-author:YasutomiDD
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
230-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8660864-Amino Acid Sequence,
pubmed-meshheading:8660864-Animals,
pubmed-meshheading:8660864-Central Nervous System,
pubmed-meshheading:8660864-Cloning, Molecular,
pubmed-meshheading:8660864-DNA, Complementary,
pubmed-meshheading:8660864-Drosophila,
pubmed-meshheading:8660864-Drosophila Proteins,
pubmed-meshheading:8660864-Gene Expression Regulation, Developmental,
pubmed-meshheading:8660864-Intermediate Filament Proteins,
pubmed-meshheading:8660864-Mice,
pubmed-meshheading:8660864-Mice, Inbred ICR,
pubmed-meshheading:8660864-Molecular Sequence Data,
pubmed-meshheading:8660864-Nerve Tissue Proteins,
pubmed-meshheading:8660864-RNA, Messenger,
pubmed-meshheading:8660864-RNA-Binding Proteins,
pubmed-meshheading:8660864-Ribonucleoproteins,
pubmed-meshheading:8660864-Sequence Homology, Amino Acid,
pubmed-meshheading:8660864-Stem Cells,
pubmed-meshheading:8660864-Xenopus,
pubmed-meshheading:8660864-Xenopus Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell.
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pubmed:affiliation |
Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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