Linked Life Data

8660457

Source:http://linkedlifedata.com/resource/pubmed/id/8660457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-10-27
pubmed:abstractText
In order to test whether mutations affecting transcription also affect DNA recombination, we have determined the influence of a number of snf/swi and spt/sin transcriptional regulatory mutations on the recombination of a DNA inverted repeat. Among the nine different mutations analyzed, we found that spt4 and spt6 confer a significant hyper-recombination phenotype. Both mutations produced increases in the frequencies of reciprocal exchange/gene conversion and deletion events ranging from 1- to 15-fold above the wild-type levels, as determined in six direct repeat systems and one inverted repeat. The frequency of mitotic recombination between homologs, determined at one chromosomal locus, was not affected. We discuss the intrachromosomal hyper-recombination phenotype of spt4 an spt6 on the basis of the possible functions of SPT4 and SPT6 on transcriptional regulation and on chromatin structure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0172-8083
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae.
pubmed:affiliation
Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't