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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1996-8-1
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|
pubmed:abstractText |
El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El mice in a dose-dependent manner. Furthermore, thrombin-treated mice manifested no convulsions, but thrombin receptor activating peptide-treated ones had convulsions. These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
5
|
|
pubmed:volume |
223
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
60-3
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8660379-Animals,
pubmed-meshheading:8660379-Anticonvulsants,
pubmed-meshheading:8660379-Disease Models, Animal,
pubmed-meshheading:8660379-Epilepsy, Tonic-Clonic,
pubmed-meshheading:8660379-Humans,
pubmed-meshheading:8660379-Male,
pubmed-meshheading:8660379-Mice,
pubmed-meshheading:8660379-Mice, Neurologic Mutants,
pubmed-meshheading:8660379-Oligopeptides,
pubmed-meshheading:8660379-Platelet-Derived Growth Factor,
pubmed-meshheading:8660379-Receptors, Thrombin,
pubmed-meshheading:8660379-Recombinant Proteins,
pubmed-meshheading:8660379-Seizures,
pubmed-meshheading:8660379-Thrombin,
pubmed-meshheading:8660379-Time Factors
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El.
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|
pubmed:affiliation |
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
