Linked Life Data

8660337

Source:http://linkedlifedata.com/resource/pubmed/id/8660337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-7-29
pubmed:abstractText
With fluorescence microscopic imaging, we have demonstrated that the Ca2+ signaling occurred in individual Calcium Green-1 loaded bovine adrenal fasciculata cells upon stimulation with adrenocorticotropin (ACTH) at physiological concentration of 0.1-100 pM. We observed three patterns of Ca2+ signaling which were Ca2+ oscillations (33%), step-like increase in Ca2+ concentration (10%), and Ca2+ oscillations superimposed on step-like increase in Ca2+ (57%). The oscillation in intracellular Ca2+ concentration occurred with a frequency around 0.04 Hz. When Ca2+ signaling upon ACTH stimulation was inhibited by the treatment with EGTA, the corticoid production was considerably suppressed. The results suggest that the Ca2+ signaling is a probable candidate of the second messenger for ACTH-induced steroid hormone synthesis in zona fasciculata cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
221
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Adrenocorticotropin induces calcium oscillations in adrenal fasciculata cells: single cell imaging.
pubmed:affiliation
Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't