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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-8-1
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pubmed:abstractText |
Predominant tubulointerstitial lupus nephritis is rare. Only eight cases have been described in the literature. We report the case of a 59-year-old man with systemic lupus erythematosus who presented with acute renal failure. On renal biopsy, he was found to have chronic tubulointerstitial nephritis with a mononuclear infiltrate. The immunofluorescence showed immune deposits in the tubular basement membranes, interstitium, and glomerular capsule. The glomeruli were minimally involved. He was initially treated with high-dose corticosteroids and supported with hemodialysis. Renal function improved and dialysis was discontinued after three treatments. The corticosteroid dosage was gradually tapered. Renal function after 72 months of follow-up has remained stable (serum creatinine, approximately 1.9 mg/dL) and except for one relapse, there has been no clinical or serologic evidence of lupus activity. Furthermore, 24-hour urinary protein excretion has remained within the normal range.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0272-6386
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8659506-Acute Kidney Injury,
pubmed-meshheading:8659506-Glucocorticoids,
pubmed-meshheading:8659506-Humans,
pubmed-meshheading:8659506-Kidney Glomerulus,
pubmed-meshheading:8659506-Kidney Tubules,
pubmed-meshheading:8659506-Lupus Nephritis,
pubmed-meshheading:8659506-Male,
pubmed-meshheading:8659506-Middle Aged,
pubmed-meshheading:8659506-Nephritis, Interstitial,
pubmed-meshheading:8659506-Prednisone
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pubmed:year |
1996
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pubmed:articleTitle |
Predominant tubulointerstitial lupus nephritis.
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pubmed:affiliation |
Division of Nephrology, New England Medical Center, Boston, MA 02111, USA.
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pubmed:publicationType |
Journal Article,
Review,
Case Reports
|