| pubmed-article:8656671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0919528 | lld:lifeskim |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0220615 | lld:lifeskim |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0333684 | lld:lifeskim |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0332597 | lld:lifeskim |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:8656671 | lifeskim:mentions | umls-concept:C0075804 | lld:lifeskim |
| pubmed-article:8656671 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8656671 | pubmed:dateCreated | 1996-7-26 | lld:pubmed |
| pubmed-article:8656671 | pubmed:abstractText | Rearrangement of the MLL (myeloid-lymphoid or mixed-lineage leukemia) gene through a reciprocal chromosomal translocation is found in 5% of adult acute myeloid (AML) and 10% of pediatric acute lymphoid (ALL) leukemia. More than 25 different reciprocal chromosomal translocations, with an 11q23 breakpoint, fuse the MLL gene (also named ALL-1, HRX and Htrx1) to a second partner gene. These leukemias have poor prognosis and frequently have a monocytic, lymphoid or biphenotypic (myeloid and lymphoid) antigen expression in blast cells. Approximately 20-30% of patients diagnosed as having adult de novo, AML have normal chromosomes by metaphase analysis and the majority of these patients have good prognosis. With the use of reverse transcriptase-polymerase chain reaction (RT-PCR) technique and Southern blot analysis, we found that seven of 34 such patients (21%) had a tandem partial duplication of exons 2 to 6 or 2 to 8 of the MLL gene. These seven patients showed a median survival of 2.7 months, compared to a 6.8 months median survival for all other patients in the study. If confirmed on a large series of patients, our findings may help differentiate AML with normal karyotype and poor prognosis from those with normal karyotype and a more favorable prognosis. | lld:pubmed |
| pubmed-article:8656671 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8656671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8656671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8656671 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8656671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8656671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8656671 | pubmed:month | May | lld:pubmed |
| pubmed-article:8656671 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:8656671 | pubmed:author | pubmed-author:YunisJ JJJ | lld:pubmed |
| pubmed-article:8656671 | pubmed:author | pubmed-author:YuMM | lld:pubmed |
| pubmed-article:8656671 | pubmed:author | pubmed-author:LiuJ CJC | lld:pubmed |
| pubmed-article:8656671 | pubmed:author | pubmed-author:PaiettaEE | lld:pubmed |
| pubmed-article:8656671 | pubmed:author | pubmed-author:AndersenJJ | lld:pubmed |
| pubmed-article:8656671 | pubmed:author | pubmed-author:HonokiKK | lld:pubmed |
| pubmed-article:8656671 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8656671 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8656671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8656671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8656671 | pubmed:pagination | 774-80 | lld:pubmed |
| pubmed-article:8656671 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8656671 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8656671 | pubmed:articleTitle | MLL tandem duplication and multiple splicing in adult acute myeloid leukemia with normal karyotype. | lld:pubmed |
| pubmed-article:8656671 | pubmed:affiliation | Cancer Biology Division, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. | lld:pubmed |
| pubmed-article:8656671 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8656671 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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