Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-7-26
|
| pubmed:abstractText |
Rearrangement of the MLL (myeloid-lymphoid or mixed-lineage leukemia) gene through a reciprocal chromosomal translocation is found in 5% of adult acute myeloid (AML) and 10% of pediatric acute lymphoid (ALL) leukemia. More than 25 different reciprocal chromosomal translocations, with an 11q23 breakpoint, fuse the MLL gene (also named ALL-1, HRX and Htrx1) to a second partner gene. These leukemias have poor prognosis and frequently have a monocytic, lymphoid or biphenotypic (myeloid and lymphoid) antigen expression in blast cells. Approximately 20-30% of patients diagnosed as having adult de novo, AML have normal chromosomes by metaphase analysis and the majority of these patients have good prognosis. With the use of reverse transcriptase-polymerase chain reaction (RT-PCR) technique and Southern blot analysis, we found that seven of 34 such patients (21%) had a tandem partial duplication of exons 2 to 6 or 2 to 8 of the MLL gene. These seven patients showed a median survival of 2.7 months, compared to a 6.8 months median survival for all other patients in the study. If confirmed on a large series of patients, our findings may help differentiate AML with normal karyotype and poor prognosis from those with normal karyotype and a more favorable prognosis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0887-6924
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
774-80
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8656671-Acute Disease,
pubmed-meshheading:8656671-Adult,
pubmed-meshheading:8656671-Base Sequence,
pubmed-meshheading:8656671-Bone Marrow,
pubmed-meshheading:8656671-Chromosomes, Human, Pair 11,
pubmed-meshheading:8656671-DNA-Binding Proteins,
pubmed-meshheading:8656671-Exons,
pubmed-meshheading:8656671-Female,
pubmed-meshheading:8656671-Humans,
pubmed-meshheading:8656671-Karyotyping,
pubmed-meshheading:8656671-Leukemia, Myeloid,
pubmed-meshheading:8656671-Male,
pubmed-meshheading:8656671-Middle Aged,
pubmed-meshheading:8656671-Molecular Sequence Data,
pubmed-meshheading:8656671-Multigene Family,
pubmed-meshheading:8656671-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:8656671-Neoplasm Proteins,
pubmed-meshheading:8656671-Polymerase Chain Reaction,
pubmed-meshheading:8656671-Prognosis,
pubmed-meshheading:8656671-Proto-Oncogenes,
pubmed-meshheading:8656671-RNA Splicing,
pubmed-meshheading:8656671-Survival Rate,
pubmed-meshheading:8656671-Transcription Factors,
pubmed-meshheading:8656671-Translocation, Genetic
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
MLL tandem duplication and multiple splicing in adult acute myeloid leukemia with normal karyotype.
|
| pubmed:affiliation |
Cancer Biology Division, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|