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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-7-31
|
| pubmed:abstractText |
A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (> 3.77 nmol/mL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29-6.35; P = .01; median permanence time in stage A2, 17 vs. 30.5 months; P = .03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and beta 2-microglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, > 31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
174
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
199-203
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8655995-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8655995-Adult,
pubmed-meshheading:8655995-CD4-CD8 Ratio,
pubmed-meshheading:8655995-Disease Progression,
pubmed-meshheading:8655995-Female,
pubmed-meshheading:8655995-HIV-1,
pubmed-meshheading:8655995-Humans,
pubmed-meshheading:8655995-Male,
pubmed-meshheading:8655995-Middle Aged,
pubmed-meshheading:8655995-Odds Ratio,
pubmed-meshheading:8655995-Predictive Value of Tests,
pubmed-meshheading:8655995-Prognosis,
pubmed-meshheading:8655995-Proportional Hazards Models,
pubmed-meshheading:8655995-Prospective Studies,
pubmed-meshheading:8655995-Pseudouridine,
pubmed-meshheading:8655995-Pyridones,
pubmed-meshheading:8655995-Ribonucleosides,
pubmed-meshheading:8655995-Time Factors,
pubmed-meshheading:8655995-beta 2-Microglobulin
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Pseudouridine and 1-ribosylpyridin-4-one-3-carboxamide (PCNR) serum concentrations in human immunodeficiency virus type 1-infected patients are independent predictors for AIDS progression.
|
| pubmed:affiliation |
Dipartimento di Biochimica e Biotecnologie Mediche, Università degli Studi di Napoli, Federico II, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|