|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1996-8-1
|
|
pubmed:abstractText |
Thrombin may have a pivotal role in restenosis after angioplasty. Hirudin, a potent thrombin inhibitor, reduces luminal narrowing by plaque after angioplasty in a rabbit model of atherosclerosis. Because cellular proliferation is believed to be an important mechanism for restenosis and thrombin has been shown to be a potent smooth muscle cell mitogen in vitro, we hypothesized that the mechanism of the effect of hirudin on limiting luminal narrowing by plaque occurs via inhibition of cellular proliferation.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0009-7322
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
93
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1194-200
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:8653841-Angioplasty, Balloon,
pubmed-meshheading:8653841-Animals,
pubmed-meshheading:8653841-Anticoagulants,
pubmed-meshheading:8653841-Arteriosclerosis,
pubmed-meshheading:8653841-Bromodeoxyuridine,
pubmed-meshheading:8653841-Cell Division,
pubmed-meshheading:8653841-Hirudins,
pubmed-meshheading:8653841-Male,
pubmed-meshheading:8653841-Partial Thromboplastin Time,
pubmed-meshheading:8653841-Rabbits,
pubmed-meshheading:8653841-Recombinant Proteins,
pubmed-meshheading:8653841-Thrombin,
pubmed-meshheading:8653841-Thymidine
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits.
|
|
pubmed:affiliation |
Cardiovascular Division, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
