Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-7-29
|
| pubmed:abstractText |
The chemotaxis of human malignant plasma cells is promoted by two extracellular matrix proteins (ECMs): fibronectin (FN) and laminin (LN). We examined the effect of the supernatant from a bone marrow stroma cell line, KM-101, on the chemotaxis of human malignant plasma cell lines to assess the chemotaxis-regulatory roles of the bone marrow microenvironment. Five human malignant plasma cell lines, FR4ds, OPM-1ds, U266/B1, RPMI-8226 and ARH-77 showed different profiles of the expression of beta 1 integrins of FN and LN receptors. FR4ds, OPM-1ds and U266/B1 cells showed chemotaxis promoted by FN (ChFN) and LN (ChLN). ARH-77 cells showed ChFN but not ChLN. RPMI-8226 cells did not show either ChFN or ChLN. The supernatant from KM-101 cells inhibited the chemotaxis of each of these cell lines regardless of whether the chemotaxis was promoted by FN or LN. Among the cytokines produced by KM-101 cells, it was postulated that IL-6 mediated this inhibitory effect because anti-IL-6 monoclonal antibody (MoAb) and anti-IL-6 receptor MoAb significantly reversed the inhibition. Recombinant IL-6 (rIL-6) also exhibited a similar inhibitory effect. Because anti-gp130 MoAb significantly reversed the chemotaxis inhibitory effect of rIL-6, the inhibitory signal is probably transduced via the signal transducing receptor component, gp130. The chemotaxis-regulatory effect is another previously unrecognized function of this pleiotropic cytokine, IL-6. High levels of IL-6 in the bone marrow microenvironment of patients with multiple myeloma appears to be favourable for the localization of myeloma cells there.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibronectin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Granulocyte...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Laminin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
534-41
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8652370-Antigens, CD,
pubmed-meshheading:8652370-Cell Division,
pubmed-meshheading:8652370-Cell Line,
pubmed-meshheading:8652370-Chemotaxis,
pubmed-meshheading:8652370-Humans,
pubmed-meshheading:8652370-Interleukin-6,
pubmed-meshheading:8652370-Leukemia, Plasma Cell,
pubmed-meshheading:8652370-Plasma Cells,
pubmed-meshheading:8652370-Plasmacytoma,
pubmed-meshheading:8652370-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:8652370-Receptors, Fibronectin,
pubmed-meshheading:8652370-Receptors, Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:8652370-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:8652370-Receptors, Interleukin,
pubmed-meshheading:8652370-Receptors, Interleukin-6,
pubmed-meshheading:8652370-Receptors, Laminin,
pubmed-meshheading:8652370-Tumor Cells, Cultured
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Interleukin-6 inhibits the chemotaxis of human malignant plasma cell lines.
|
| pubmed:affiliation |
Department of Haematology and Oncology, Osaka University Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|