Linked Life Data

8651947

Source:http://linkedlifedata.com/resource/pubmed/id/8651947

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1996-7-25
pubmed:abstractText
Tyrosine-phosphorylated signal transducer and activator of transcription 1 alpha (STAT1 alpha) is a 91-kDa protein responsible for interferon-gamma (IFN-gamma)-dependent transcription. The present study demonstrates that activation by IFN-gamma of murine macrophages resulted in tyrosine phosphorylation of STAT1 alpha identified by immunoprecipitation. The tyrosine phosphorylation of STAT1 alpha was found highly sensitive to treatment by delta-9 tetrahydrocannabinol (THC), a major marijuana component. Subsequently, the isoform formation of p91 due to tyrosine phosphorylation was reduced in THC-treated macrophages. Although inhibition by THC of the tyrosine phosphorylation of STAT1 alpha induced by IFN-gamma was in a THC concentration-related manner, the tyrosine phosphorylation of other proteins induced by lipopolysaccharide/IFN-gamma treatment of macrophages appeared insensitive to THC treatment. Our data suggest that blockade by THC of tyrosine phosphorylation of STAT1 alpha may be an important mechanism involved in the broad immunosuppressive effects of THC.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
967-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Delta-9-tetrahydrocannabinol: an inhibitor of STAT1 alpha protein tyrosine phosphorylation.
pubmed:affiliation
Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.