Linked Life Data

8651308

Source:http://linkedlifedata.com/resource/pubmed/id/8651308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-7-25
pubmed:abstractText
The origins of the inhabitants of Madagascar have not been fully resolved. Anthropological studies and preliminary genetic data point to two main sources of ancestry of the Malagasy, namely, Indonesian and African, with additional contributions from India and Arabia. The sickle-cell (beta s) mutation is found in populations of African and Indian origin. The frequency of the beta s-globin gene, derived from 1,425 Malagasy individuals, varies from 0 in some highland populations to .25 in some coastal populations. The beta s mutation is thought to have arisen at least five times, on the basis of the presence of five distinct beta s-associated haplotypes, each found in a separate geographic area. Twenty-five of the 35 Malagasy beta s haplotypes were of the typical "Bantu" type, 1 "Senegal" haplotype was found, and 2 rare or atypical haplotypes were observed; the remaining 7 haplotypes were consistent with the Bantu haplotype. The Bantu beta s mutation is thought to have been introduced into Madagascar by Bantu-speaking immigrants (colonists or slaves) from central or east Africa. The Senegal beta s mutation may have been introduced to the island via Portuguese naval explorers. This study provides the first definitive biological evidence that a major component of Malagasy ancestry is derived from African populations, in particular, Bantu-speaking Negroids. beta A haplotypes are also consistent with the claim for a significant African contribution to Malagasy ancestry but are also suggestive of Asian/Oceanic and Caucasoid admixture within the Malagasy population.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-13424674, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-1376298, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-1511179, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-1680511, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-2255919, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-2412616, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-2731937, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-3344216, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-3752087, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-461196, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-6256028, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-6584911, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-8353314, http://linkedlifedata.com/resource/pubmed/commentcorrection/8651308-8462981
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1303-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Beta-globin haplotype analysis suggests that a major source of Malagasy ancestry is derived from Bantu-speaking Negroids.
pubmed:affiliation
Department of Human Genetics, School of Pathology, The South African Institute for Medical Research, Johannesburg, South Africa.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't