Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-7-19
pubmed:abstractText
The process of ageing involves many changes in the skin. These changes are not necessarily uniform, so the pattern of regional variations may vary with ageing. The aim of the present study was to assess age-related regional variations in skin function, by measuring the cutaneous microvascular response to histamine. Histamine was topically applied to the back and forearm of a young and an aged group of volunteers (n = 28, 14 in each group), and the response was quantified utilizing laser Doppler flowmetry. The following parameters were calculated from the data and compared between the two groups: (i) peak response; (ii) the time required to reach the peak; (iii) the time required to decay to half the peak flow; and (iv) the area under the response time curve. For the young group, the magnitude of the maximum response, as well as the extent of the response as measured by the area under the response curve, were significantly greater on the back than on the forearm (p < 0.01 and p < 0.05, respectively). In contrast, for the aged group, the two sites did not significantly differ from each other. The time required to reach the peak was longer in the aged group over both sites, and so was the time required to decay to half the peak flow. These observations indicate regional anatomical or functional differences between old and young skin, which may provide insight into inherent differences influencing cutaneous manifestations of endogenous and exogenous diseases in various age groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0001-5555
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Age-related regional variations of human skin blood flow response to histamine.
pubmed:affiliation
Department of Dermatology, Elias-Sourasky Medical Center, Tel Aviv University, Israel.
pubmed:publicationType
Journal Article