Linked Life Data

8649466

Source:http://linkedlifedata.com/resource/pubmed/id/8649466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-7-25
pubmed:abstractText
The w/w+ somatic mutation and recombination test (SMART) of Drosophila melanogaster is a fast and low cost in vivo assay that has shown excellent results in the assessment of genotoxicity of a large number of compounds. However, recent studies have revealed that, when procarcinogens are to be evaluated, the performance of the assay is largely dependent on the genetic background of the strains used. To determine which one of the strains available for this test would be advisable to evaluate agents producing reactive oxygen species we have used two approaches. Firstly, the w/w+ assay was carried out using 6 different strains and two compounds: menadione and paraquat. Secondly, 3 biochemical traits were determined for the 6 strains: superoxide dismutase and catalase activities, and their capacity to induce reactive oxygen species. The results suggest that the strains Oregon K and Haag 79 would be usable when potential inducers of reactive oxygen species are to be investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
360
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The w/w+ somatic mutation and recombination test (SMART) of Drosophila melanogaster for detecting reactive oxygen species: characterization of 6 strains.
pubmed:affiliation
Departamento de Biología Funcional, Universidad de Oviedo, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't