Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-7-22
pubmed:databankReference
pubmed:abstractText
SR 31747 is a novel immunosuppressant agent that arrests cell proliferation in the yeast Saccharomyces cerevisiae, SR 31747-treated cells accumulate the same aberrant sterols as those found in a mutant impaired in delta 8- delta 7-sterol isomerase. Sterol isomerase activity is also inhibited by SR 31747 in in vitro assays. Overexpression of the sterol isomerase-encoding gene, ERG2, confers enhanced SR resistance. Cells growing anaerobically on ergosterol-containing medium are not sensitive to SR. Disruption of the sterol isomerase-encoding gene is lethal in cells growing in the absence of exogenous ergosterol, except in SR-resistant mutants lacking either the SUR4 or the FEN1 gene product. The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1293881, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-13034889, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1377361, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1394506, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1452020, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1493925, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1655424, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1705713, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1776363, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1776366, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1779706, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1779709, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1955564, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-1964349, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2001673, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2191067, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2203312, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2438691, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2556364, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2591378, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-2681155, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-6336730, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-6338497, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-6546423, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-7548216, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-7694398, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-7736604, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-7791529, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-7794416, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-7891662, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-8008069, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-8027068, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-8034758, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-8125337, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-8246690, http://linkedlifedata.com/resource/pubmed/commentcorrection/8649379-8488727
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2719-27
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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