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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1996-7-25
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pubmed:abstractText |
Thirty-five aggressive non-Hodgkin's lymphomas (NHL) with marrow involvement received high-dose cyclophosphamide (7 g/m2) and G-CSF in order to collect peripheral blood progenitor cells (PBPC). Fourteen patients were in partial remission, 16 patients were in relapse ('sensitive', 12; 'resistant', 4) and five patients were refractory to conventional treatment. A good yield of PBPC was obtained in 30 patients, while a low number of CD34+ cells and of CFU-GM was seen in two cases. Two patients entered progression and one patient died. Thirty patients underwent PBPC autografting. Twenty-nine out of 35 (83%) patients entered complete remission (CR). Two patients died in CR of infection following marrow aplasia 3 and 6 months after autografting. At 3 years the probability of survival and disease-free survival (DFS) are 62 and 51%, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0887-6924
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pubmed:author |
pubmed-author:BenvenutoFF,
pubmed-author:BruniRR,
pubmed-author:ChisesiTT,
pubmed-author:CongiuA MAM,
pubmed-author:FigariOO,
pubmed-author:GobbiMM,
pubmed-author:MiglinoMM,
pubmed-author:NatiSS,
pubmed-author:PiaggioGG,
pubmed-author:PierluigiDD,
pubmed-author:RavettiJ LJL,
pubmed-author:RossiEE,
pubmed-author:SantiniGG,
pubmed-author:SertoliM RMR,
pubmed-author:SoraccoMM,
pubmed-author:SprianoMM,
pubmed-author:TruiniMM,
pubmed-author:VassalliLL,
pubmed-author:VimercatiRR
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pubmed:issnType |
Print
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pubmed:volume |
10 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
s88-91
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8649061-Adult,
pubmed-meshheading:8649061-Antineoplastic Agents, Alkylating,
pubmed-meshheading:8649061-Combined Modality Therapy,
pubmed-meshheading:8649061-Cyclophosphamide,
pubmed-meshheading:8649061-Female,
pubmed-meshheading:8649061-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:8649061-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:8649061-Humans,
pubmed-meshheading:8649061-Leukapheresis,
pubmed-meshheading:8649061-Lymphoma, Non-Hodgkin,
pubmed-meshheading:8649061-Male,
pubmed-meshheading:8649061-Middle Aged,
pubmed-meshheading:8649061-Pilot Projects,
pubmed-meshheading:8649061-Survival Analysis
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pubmed:year |
1996
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pubmed:articleTitle |
Mobilization/transplantation of peripheral blood progenitor cells for aggressive non-Hodgkin's lymphoma with marrow involvement.
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pubmed:affiliation |
Department of Hematology, Ospedale S Martino, Genova, Italy.
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pubmed:publicationType |
Journal Article
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