| pubmed-article:8648649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C0038975 | lld:lifeskim |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C0030176 | lld:lifeskim |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C1313915 | lld:lifeskim |
| pubmed-article:8648649 | lifeskim:mentions | umls-concept:C0425087 | lld:lifeskim |
| pubmed-article:8648649 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8648649 | pubmed:dateCreated | 1996-7-25 | lld:pubmed |
| pubmed-article:8648649 | pubmed:abstractText | Using the experimental system of simian virus 40 (SV40) pseudovirions we have previously shown that SV40 requires a specific DNA element for packaging, ses, which was mapped to the SV40 regulatory region. ses was previously found to play a role in facilitating the nucleosomal rearrangement required for chromatin condensation and viral packaging. Here, the fine structure of ses was investigated by genetic studies. Analyses of ses+ revertants indicated that in order to function, ses must be present in close proximity to the origin of replication (ori), supporting a role in the regulation of the viral life cycle. Fine dissection of ses was performed using a series of plasmids carrying mutations and deletions in this region. The results suggest that multiple DNA elements participate in the SV40 packaging process, including the GC-boxes and elements derived from the enhancer. The elements are redundant, and they can function in various combinations. Packaging efficiency correlated with the number of GC-boxes, known to bind Sp1. In addition, AP-2 binding elements appeared to more important than others. These findings were supported by experiments which showed that packaging was significantly enhanced by adding AP-2 binding sites to plasmids with large deletions and lacking those sites. The results imply that binding of Sp1 and/or AP-2 may participate in the packaging process. | lld:pubmed |
| pubmed-article:8648649 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8648649 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648649 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8648649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8648649 | pubmed:month | May | lld:pubmed |
| pubmed-article:8648649 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:8648649 | pubmed:author | pubmed-author:OppenheimAA | lld:pubmed |
| pubmed-article:8648649 | pubmed:author | pubmed-author:Dalyot-Herman... | lld:pubmed |
| pubmed-article:8648649 | pubmed:author | pubmed-author:Ben-nun-Shaul... | lld:pubmed |
| pubmed-article:8648649 | pubmed:author | pubmed-author:Gordon-ShaagA... | lld:pubmed |
| pubmed-article:8648649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8648649 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:8648649 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:8648649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8648649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8648649 | pubmed:pagination | 69-80 | lld:pubmed |
| pubmed-article:8648649 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:meshHeading | pubmed-meshheading:8648649-... | lld:pubmed |
| pubmed-article:8648649 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8648649 | pubmed:articleTitle | The simian virus 40 packaging signal ses is composed of redundant DNA elements which are partly interchangeable. | lld:pubmed |
| pubmed-article:8648649 | pubmed:affiliation | Department of Hematology, Hebrew University Hadassah Medical School, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:8648649 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8648649 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8648649 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8648649 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8648649 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8648649 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8648649 | lld:pubmed |
