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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1996-7-25
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pubmed:abstractText |
In genetically occurring non-insulin-dependent diabetes mellitus (NIDDM) model rats (GK rats), the activities of L- and T-type Ca2+ channels in pancreatic beta cells are found to be augmented, by measuring the Ba2+ currents via these channels using whole-cell patch-clamp technique, while the patterns of the current-voltage curves are indistinguishable. The hyper-responsiveness of insulin secretion to nonglucose depolarizing stimuli observed in NIDDM beta cells could be the result, therefore, of increased voltage-dependent Ca2+ channel activity. Perforated patch-clamp recordings reveal that the augmentation of L-type Ca2+ channel activity by glucose is markedly less pronounced in GK beta cells than in control beta cells, while glucose-induced augmentation of T-type Ca2+ channel activity is observed neither in the control nor in the GK beta cells. This lack of glucose-induced augmentation of L-type Ca2+ channel activity in GK beta cells might be causatively related to the selective impairment of glucose-induced insulin secretion in NIDDM beta cells, in conjunction with an insufficient plasma membrane depolarization due to impaired closure of the ATP-sensitive K+ channels caused by the disturbed intracellular glucose metabolism in NIDDM beta cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1309948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1373869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1402665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1556189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1559411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1657671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-1787535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-2010050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-2458427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-2479839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-2633909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-2862019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-6341128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-7526124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-7686306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-7867879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-7988773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-8023914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-8262306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-8300606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-8355424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8647933-8375584
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:HorieMM,
pubmed-author:IkedaII,
pubmed-author:IkeharaSS,
pubmed-author:IshidaHH,
pubmed-author:KatoSS,
pubmed-author:NishimuraMM,
pubmed-author:OdakaHH,
pubmed-author:OkadaYY,
pubmed-author:SeinoYY,
pubmed-author:TaminatoTT,
pubmed-author:TsujiKK,
pubmed-author:TsuuraYY
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2417-25
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8647933-Animals,
pubmed-meshheading:8647933-Calcium,
pubmed-meshheading:8647933-Calcium Channels,
pubmed-meshheading:8647933-Calcium Channels, L-Type,
pubmed-meshheading:8647933-Cells, Cultured,
pubmed-meshheading:8647933-Diabetes Mellitus, Type 2,
pubmed-meshheading:8647933-Glucose,
pubmed-meshheading:8647933-Insulin,
pubmed-meshheading:8647933-Islets of Langerhans,
pubmed-meshheading:8647933-Male,
pubmed-meshheading:8647933-Membrane Potentials,
pubmed-meshheading:8647933-Models, Biological,
pubmed-meshheading:8647933-Nitrendipine,
pubmed-meshheading:8647933-Patch-Clamp Techniques,
pubmed-meshheading:8647933-Potassium,
pubmed-meshheading:8647933-Rats,
pubmed-meshheading:8647933-Rats, Mutant Strains,
pubmed-meshheading:8647933-Rats, Wistar,
pubmed-meshheading:8647933-Reference Values
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pubmed:year |
1996
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pubmed:articleTitle |
Alterations in basal and glucose-stimulated voltage-dependent Ca2+ channel activities in pancreatic beta cells of non-insulin-dependent diabetes mellitus GK rats.
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pubmed:affiliation |
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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