Linked Life Data

8647788

Source:http://linkedlifedata.com/resource/pubmed/id/8647788

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-7-19
pubmed:abstractText
The treatment of depression can be problematic in the elderly patient. The advent of the serotonin selective reuptake inhibitors (SSRIs) represents a significant advance in the treatment of depression. Sufficient data from controlled studies now exist on the efficacy and safety of these agents in geriatric patients to recommend them as a primary treatment for major depressive disorder. SSRIs appear to have significant advantages over older drugs, especially tricyclic agents, in this age group. The lack of significant anticholinergic and antihistaminergic side effects results in better tolerability and better compliance. While SSRIs are not free of side effects, those that occur can usually be managed in the context of continued treatment of the depressive episode. This article reviews data from controlled studies of the treatment of geriatric depression for all four available SSRIs in the United States-fluoxetine, sertraline, paroxetine, and fluvoxamine (which is approved in the United States for treating only obsessive-compulsive disorder). Differences among the SSRIs are examined, particularly with reference to clinically relevant differences in pharmacokinetics and hepatic isoenzyme inhibition. Principles of clinical management are discussed, including dose initiation and titration, side effect management, augmentation and combinations, and length of treatment. Finally, the use of SSRIs in special elderly populations is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0160-6689
pubmed:author
pubmed:issnType
Print
pubmed:volume
57 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Use of serotonin selective reuptake inhibitors in geriatric depression.
pubmed:affiliation
Geriatric Psychiatry Service, University of Vermont College of Medicine, Burlington 05401, USA.
pubmed:publicationType
Journal Article, Review