Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1996-7-19
|
| pubmed:abstractText |
Awareness of the virulence of coagulase-negative Staphylococci, previously regarded as saprophytes with minimal pathogenicity, has steadily increased. Eighty-seven individual patients diagnosed with acute osteomyelitis, as confirmed by microbiologic and pathologic analysis, were included in this study. Of these patients, 82% (71/87) were known to have diabetes mellitus. The prevalence of coagulase negative Staphylococcus was 40% (35/87) in deep bone cultures, 63% (22/35) of which were methicillin resistant. When the coagulase negative Staphylococcus group was assessed for prior long-term (> 2 week) oral antibiotic treatment with ciprofloxacin, it was found that 54% (12/22) of the methicillin-resistant coagulase-negative Staphylococcal infected patients had received such treatment, compared with 15% (2/13) of patients with methicillin-sensitive coagulase-negative Staphylococcal osteomyelitis (p < 0.034). When the group was analyzed for prior long-term antibiotic treatment with amoxicillin/clavulanate, 23% (5/22) of the methicillin-resistant patients had received oral amoxicillin/clavulanate, compared with 23% (3/13) of patients with methicillin-sensitive coagulase-negative Staphylococcal osteomyelitis (p > 0.05). Prevalence of polymicrobial infections, which constituted 29% (25/87) of all individual patients, was also analyzed. Of those patients with coagulase-negative isolates, 29% (10/35) were polymicrobial (p > 0.05). The results from this study suggest that infections of bone caused by coagulase-negative Staphylococci are associated with a high prevalence of methicillin resistance. This study also raises the question of whether injudicious prolonged use of ciprofloxacin may, in fact, promote proliferation of resistant organism strains.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ciprofloxacin,
http://linkedlifedata.com/resource/pubmed/chemical/Clavulanic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Clavulanic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Coagulase
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1067-2516
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
563-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8646208-Acute Disease,
pubmed-meshheading:8646208-Aged,
pubmed-meshheading:8646208-Amoxicillin,
pubmed-meshheading:8646208-Anti-Bacterial Agents,
pubmed-meshheading:8646208-Ciprofloxacin,
pubmed-meshheading:8646208-Clavulanic Acid,
pubmed-meshheading:8646208-Clavulanic Acids,
pubmed-meshheading:8646208-Coagulase,
pubmed-meshheading:8646208-Diabetes Complications,
pubmed-meshheading:8646208-Diabetes Mellitus,
pubmed-meshheading:8646208-Female,
pubmed-meshheading:8646208-Humans,
pubmed-meshheading:8646208-Male,
pubmed-meshheading:8646208-Methicillin Resistance,
pubmed-meshheading:8646208-Middle Aged,
pubmed-meshheading:8646208-Osteomyelitis,
pubmed-meshheading:8646208-Staphylococcal Infections,
pubmed-meshheading:8646208-Staphylococcus
|
| pubmed:articleTitle |
Methicillin-resistant coagulase-negative staphylococcal osteomyelitis and its relationship to broad-spectrum oral antibiosis in a predominantly diabetic population.
|
| pubmed:affiliation |
Department of Podiatric Surgery, Monsignor Clement Kern Hospital for Special Surgery, Warren, Michigan, USA.
|
| pubmed:publicationType |
Journal Article
|