| pubmed-article:8645960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8645960 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:8645960 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:8645960 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:8645960 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:8645960 | lifeskim:mentions | umls-concept:C0235063 | lld:lifeskim |
| pubmed-article:8645960 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8645960 | pubmed:dateCreated | 1996-7-19 | lld:pubmed |
| pubmed-article:8645960 | pubmed:abstractText | The effects of hypoxia on ventilation and cerebral activity were studied in urethane-anaesthetized newborn guinea-pigs. Ventilation was measured by a pneumotachograph, and cerebral activity by a cerebral function monitor (CFM). All animals were subjected to either 9% O2 or 6% O2 in N2 for 10 minutes or until apnoea occurred. Hypoxia produced a biphasic response in ventilation, that is, an increase followed by a decrease. The initial increase was attributed to the elevation of the respiratory rate, whereas the tidal volume showed a pure decline. The respiratory rate reached its peak at 3 minutes of hypoxia (170 +/- 12% during 9% O2 and 169 +/- 12% during 6% O2). Cerebral activity during both 9 and 6% O2 breathing showed a small increase followed by a decrease. In the group subjected to 9% O2 the maximum CFM activity increased to 114 +/- 8% of the control level and the minimum activity increased to 113 +/- 7%, while in the group subjected to 6% O2 the maximum CFM activity increased to 104 +/- 5% and the minimum CFM activity to 101 +/- 3%. The depression of CFM activity was more pronounced with 6% O2 than with 9% O2. Regression analysis showed a linear correlation between ventilation and cerebral activity during both 9 and 6% O2 breathing. The results suggest that hypoxic ventilatory depression may be the consequence of cerebral depression produced by acute severe hypoxia. | lld:pubmed |
| pubmed-article:8645960 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8645960 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645960 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8645960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8645960 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8645960 | pubmed:issn | 0803-5253 | lld:pubmed |
| pubmed-article:8645960 | pubmed:author | pubmed-author:LagercrantzHH | lld:pubmed |
| pubmed-article:8645960 | pubmed:author | pubmed-author:YuanS ZSZ | lld:pubmed |
| pubmed-article:8645960 | pubmed:author | pubmed-author:RunoldMM | lld:pubmed |
| pubmed-article:8645960 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8645960 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:8645960 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8645960 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8645960 | pubmed:pagination | 1409-13 | lld:pubmed |
| pubmed-article:8645960 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:meshHeading | pubmed-meshheading:8645960-... | lld:pubmed |
| pubmed-article:8645960 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8645960 | pubmed:articleTitle | Cerebral and ventilatory depression during hypoxia in anaesthetized newborn guinea-pigs. | lld:pubmed |
| pubmed-article:8645960 | pubmed:affiliation | Nobel Institute for Neurophysiology, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:8645960 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8645960 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
