| pubmed-article:8645283 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C0734999 | lld:lifeskim |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:8645283 | lifeskim:mentions | umls-concept:C2257274 | lld:lifeskim |
| pubmed-article:8645283 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8645283 | pubmed:dateCreated | 1996-7-15 | lld:pubmed |
| pubmed-article:8645283 | pubmed:abstractText | Cyclic ADP-ribose (cADPR), a well-known stimulator of ca(2+) release from the intracellular Ca(2+) pool, has recently emerged as a potential regulator of insulin secretion in pancreatic beta cells. As recently described, BST-1 is a glycosyl-phosphatidylinositol (GPI)-anchored surface molecule that exhibits homology with CD38 and Aplysia ADP-ribosyl cyclase. Like CD38, BST-1 has both ADP-ribosyl cyclase and cADPR hydrolase activities. As a step toward elucidating the physiological role of cADPR in insulin secretion we examined whether BST-1 is expressed in pancreatic islet cells. Sensitive reverse transcription-polymerase chain reaction detected almost as abundant expression of BST-1 mRNA in pancreatic islets as CD38 mRNA. Immunohistochemical analyses utilizing mirror image sections revealed that BST-1 protein is expressed in a majority of the cells in pancreatic islets and that at least beta cells and, to an even greater extent, alpha cells express BST-1. These observations suggest the involvement of multiple enzymes in the regulation of cADPR concentrations in pancreatic islet cells. | lld:pubmed |
| pubmed-article:8645283 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8645283 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645283 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8645283 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8645283 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:YoshidaHH | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:MatsuzawaYY | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:HiranoTT | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:YamasakiYY | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:ItohMM | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:KamadaTT | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:HanafusaTT | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:IshiharaKK | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:MatsuokaTT | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:OkuyamaYY | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:FujitaniYY | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:KajimotoYY | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:KaishoTT | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:MiyagawaJJ | lld:pubmed |
| pubmed-article:8645283 | pubmed:author | pubmed-author:WatadaHH | lld:pubmed |
| pubmed-article:8645283 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8645283 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:8645283 | pubmed:volume | 219 | lld:pubmed |
| pubmed-article:8645283 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8645283 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8645283 | pubmed:pagination | 941-6 | lld:pubmed |
| pubmed-article:8645283 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8645283 | pubmed:meshHeading | pubmed-meshheading:8645283-... | lld:pubmed |
| pubmed-article:8645283 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8645283 | pubmed:articleTitle | Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. | lld:pubmed |
| pubmed-article:8645283 | pubmed:affiliation | First Department of Medicine, Osaka University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:8645283 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8645283 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8645283 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:683 | entrezgene:pubmed | pubmed-article:8645283 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8645283 | lld:pubmed |
