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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-7-15
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pubmed:abstractText |
The obese gene product, leptin, is synthesized in adipose tissue and is a circulating factor regulating body weight. To identify the location of leptin receptors in the brain we have performed an autoradiographic study of the binding of [(125)I]leptin to frozen sections of mouse brain. Dense specific binding of [(125)I]leptin was found only in the choroid plexus which is located in the dorsal part of the third ventricle and lateral ventricles. Specific binding of [(125)I]leptin was found the ob/ob and db/db mice. These findings further our understanding of the sites and mechanism of action of leptin on brain centers regulating body weight.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
219
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
884-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8645274-Animals,
pubmed-meshheading:8645274-Autoradiography,
pubmed-meshheading:8645274-Binding, Competitive,
pubmed-meshheading:8645274-Binding Sites,
pubmed-meshheading:8645274-Brain,
pubmed-meshheading:8645274-Carrier Proteins,
pubmed-meshheading:8645274-Diabetes Mellitus,
pubmed-meshheading:8645274-Female,
pubmed-meshheading:8645274-Iodine Radioisotopes,
pubmed-meshheading:8645274-Kinetics,
pubmed-meshheading:8645274-Leptin,
pubmed-meshheading:8645274-Mice,
pubmed-meshheading:8645274-Mice, Inbred C57BL,
pubmed-meshheading:8645274-Mice, Mutant Strains,
pubmed-meshheading:8645274-Mice, Obese,
pubmed-meshheading:8645274-Obesity,
pubmed-meshheading:8645274-Proteins,
pubmed-meshheading:8645274-Receptors, Cell Surface,
pubmed-meshheading:8645274-Receptors, Cytokine,
pubmed-meshheading:8645274-Receptors, Leptin,
pubmed-meshheading:8645274-Species Specificity
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pubmed:year |
1996
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pubmed:articleTitle |
Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice.
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pubmed:affiliation |
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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