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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-7-16
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pubmed:abstractText |
This report presents refined genetic mapping data for the gene causing familial Mediterranean fever (FMF), a recessively inherited disorder of inflammation. We sampled 65 Jewish, Armenian, and Arab families and typed them for eight markers from chromosome 16p. Using a new algorithm that permits multipoint calculations for a dense map of markers in consanguineous families, we obtained a maximal LOD score of 49.2 at a location 1.6 cM centromeric to D16S246. A specific haplotype at D16S283-D16S94-D16S246 was found in 76% of Moroccan and 32% of non-Moroccan Jewish carrier chromosomes, but this haplotype was not overrepresented in Armenian or Arab FMF carriers. Moreover, the 2.5-kb allele at D16S246 was significantly associated with FMF in Moroccan and non-Moroccan Jews but not in Armenians or Arabs. Since the Moroccan Jewish community represents a relatively recently established and genetically isolated founder population, we analyzed the Moroccan linkage-disequilibrium data by using Luria-Delbrück formulas and simulations based on a Poisson branching process. These methods place the FMF susceptibility gene within 0.305 cM of D16S246 (2-LOD-unit range 0.02-0.64 cM).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1198348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1345170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1436057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1463015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1579134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1683919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-17247100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-17248813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-1825014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-2884728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-3306755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-4437392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-5340644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-5794010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-6587361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7774955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7825575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7847388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7887419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7894487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7923357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7959700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7977356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-7987397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8102507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8104628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8178817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8198127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8252033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8268938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8362911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644712-8533779
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9297
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pubmed:author |
pubmed-author:AksentijevichII,
pubmed-author:BalowJ EJEJr,
pubmed-author:ChewAA,
pubmed-author:Fischel-GhodsianNN,
pubmed-author:GumucioDD,
pubmed-author:KastnerD LDL,
pubmed-author:KruglyakLL,
pubmed-author:KupelianAA,
pubmed-author:LevyE NEN,
pubmed-author:LinzerBB,
pubmed-author:PratDD,
pubmed-author:RichardsR IRI,
pubmed-author:RotterJ IJI,
pubmed-author:SOSAA RAR,
pubmed-author:SheltonD ADA,
pubmed-author:ShenYY,
pubmed-author:ShohatMM
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
523-34
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:8644712-Algorithms,
pubmed-meshheading:8644712-Alleles,
pubmed-meshheading:8644712-Arabs,
pubmed-meshheading:8644712-Armenia,
pubmed-meshheading:8644712-Chromosome Mapping,
pubmed-meshheading:8644712-Chromosomes, Human, Pair 16,
pubmed-meshheading:8644712-Computer Simulation,
pubmed-meshheading:8644712-Familial Mediterranean Fever,
pubmed-meshheading:8644712-Haplotypes,
pubmed-meshheading:8644712-Heterozygote,
pubmed-meshheading:8644712-Humans,
pubmed-meshheading:8644712-Jews,
pubmed-meshheading:8644712-Linkage Disequilibrium,
pubmed-meshheading:8644712-Morocco
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pubmed:year |
1996
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pubmed:articleTitle |
Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246.
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pubmed:affiliation |
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892-1820, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study
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