| pubmed-article:8644539 | pubmed:abstractText | The effects of amosulalol, which blocks alpha 1 adrenoceptors selectively and beta receptors nonselectively almost to the same extent, on intraocular pressure (IOP) and aqueous humor dynamics were studied in pigmented rabbits. Administration of topical amosulalol (0.5%) resulted in a significant difference in IOP between the treated and the contralateral eyes from 0.5 to 6 hours, and the maximum IOP reduction, 6.0 +/- 0.4 mmHg (mean +/- standard error), was observed at 2 hours after administration. Aqueous humor dynamics measurements (mean +/- standard error) in the amosulalol (0.5%)-treated and the contralateral eyes revealed that total outflow facility determined by the two-level constant pressure perfusion method was not significantly different, 0.14 +/- 0.01 and 0.12 +/- 0.01 microliter/min/mmHg, respectively; the aqueous flow measurements determined by fluorophotometry were 3.0 +/- 0.1 and 3.4 +/- 0.2 microliters/min, respectively (p < 0.05, -11%); the uveoscleral outflow measurements determined by the fluorescein isothiocyanate-dextran perfusion method were 0.53 +/- 0.04 and 0.46 +/- 0.04 microliter/min, respectively (p < 0.05, +15%). In conclusion, amosulalol lowers the IOP by inhibiting aqueous production and increasing uveoscleral outflow. | lld:pubmed |
