Linked Life Data

8644539

Source:http://linkedlifedata.com/resource/pubmed/id/8644539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-7-12
pubmed:abstractText
The effects of amosulalol, which blocks alpha 1 adrenoceptors selectively and beta receptors nonselectively almost to the same extent, on intraocular pressure (IOP) and aqueous humor dynamics were studied in pigmented rabbits. Administration of topical amosulalol (0.5%) resulted in a significant difference in IOP between the treated and the contralateral eyes from 0.5 to 6 hours, and the maximum IOP reduction, 6.0 +/- 0.4 mmHg (mean +/- standard error), was observed at 2 hours after administration. Aqueous humor dynamics measurements (mean +/- standard error) in the amosulalol (0.5%)-treated and the contralateral eyes revealed that total outflow facility determined by the two-level constant pressure perfusion method was not significantly different, 0.14 +/- 0.01 and 0.12 +/- 0.01 microliter/min/mmHg, respectively; the aqueous flow measurements determined by fluorophotometry were 3.0 +/- 0.1 and 3.4 +/- 0.2 microliters/min, respectively (p < 0.05, -11%); the uveoscleral outflow measurements determined by the fluorescein isothiocyanate-dextran perfusion method were 0.53 +/- 0.04 and 0.46 +/- 0.04 microliter/min, respectively (p < 0.05, +15%). In conclusion, amosulalol lowers the IOP by inhibiting aqueous production and increasing uveoscleral outflow.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0029-0203
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-83
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Effects of amosulalol hydrochloride on intraocular pressure and aqueous humor dynamics in the rabbit eye].
pubmed:affiliation
Department of Ophthalmology, Gifu University School of Medicine, Japan.
pubmed:publicationType
Journal Article, English Abstract