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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
33
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pubmed:dateCreated |
1996-7-17
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pubmed:abstractText |
The integration of genetic and biochemical approaches to study the crystal structure of the glutaminyl-tRNA synthetase (GlnRS):tRNA(Gln):ATP complex has elucidated the mechanism by which GlnRS selects its cognate tRNA for aminoacylation. Three principal types of interaction have been identified: interaction with specific bases in the cognate tRNA, rejection of non-cognate tRNAs, and activation of the active site upon cognate tRNA binding. The recent solving of the crystal structure of tryptophanyl-tRNA synthetase (TrpRS) has allowed comparable studies to be initiated in an aminoacyl-tRNA synthetase which, unlike GlnRS, does not require tRNA binding prior to amino acid activation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0261-3166
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
40-2
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8643392-Amino Acyl-tRNA Synthetases,
pubmed-meshheading:8643392-Binding Sites,
pubmed-meshheading:8643392-Escherichia coli,
pubmed-meshheading:8643392-Geobacillus stearothermophilus,
pubmed-meshheading:8643392-Glutamate-tRNA Ligase,
pubmed-meshheading:8643392-Models, Molecular,
pubmed-meshheading:8643392-Mutation,
pubmed-meshheading:8643392-Nucleic Acid Conformation,
pubmed-meshheading:8643392-Protein Conformation,
pubmed-meshheading:8643392-RNA, Transfer, Gln,
pubmed-meshheading:8643392-Substrate Specificity,
pubmed-meshheading:8643392-Tryptophan-tRNA Ligase
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pubmed:year |
1995
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pubmed:articleTitle |
Substrate selection by aminoacyl-tRNA synthetases.
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pubmed:affiliation |
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
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pubmed:publicationType |
Journal Article,
Review
|