Linked Life Data

8641561

Source:http://linkedlifedata.com/resource/pubmed/id/8641561

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-7-12
pubmed:abstractText
The endothelium is uniquely positioned at the interface between the blood and the vessel wall. As such, it performs multiple functions: It is involved in the regulation of coagulation, leukocyte adhesion in inflammation, vessel tone, and vascular smooth muscle cell growth, and also acts as a barrier to transvascular flux of liquids and solutes. Far from being a passive participant in these events, it is a dynamic tissue, secreting and modifying vasoactive substances, influencing the behavior of other cell types, and regulating extracellular matrix production and composition. During the past 20 years, the endothelium has been the focus of intense experimental work, resulting in the evolution of a new appreciation of its potential role in vascular disease. This review will concentrate on several areas of endothelial biology in which our knowledge of the molecular mechanisms regulating the function of the endothelium has expanded considerably, permitting new insights into the pathogenesis of vascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0892-6638
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-92
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Endothelial control of the cardiovascular system: recent advances.
pubmed:affiliation
Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
pubmed:publicationType
Journal Article, Review