|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1996-7-15
|
|
pubmed:abstractText |
To assess the action of RU486 (mifepristone), in the presence and absence of P, on PRL production by explant cultures of leiomyoma and myometrium.
|
|
pubmed:grant |
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Americas,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Fibroids,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Hormone Antagonists,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/MASSACHUSETTS,
http://linkedlifedata.com/resource/pubmed/keyword/Myometrium,
http://linkedlifedata.com/resource/pubmed/keyword/Neoplasms,
http://linkedlifedata.com/resource/pubmed/keyword/Neoplasms, Benign,
http://linkedlifedata.com/resource/pubmed/keyword/North America,
http://linkedlifedata.com/resource/pubmed/keyword/Northern America,
http://linkedlifedata.com/resource/pubmed/keyword/PROLACTIN,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pituitary Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Ru-486,
http://linkedlifedata.com/resource/pubmed/keyword/United States,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System,
http://linkedlifedata.com/resource/pubmed/keyword/Uterus
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0015-0282
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1119-24
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:otherAbstract |
PIP: Uterine leiomyomas are the most common benign neoplasms of the uterus. They appear to be estrogen dependent. The role of progestins in regulating leiomyoma growth is, however, less clear. Studies have suggested that RU486 may provide long-term medical treatment for women with leiomyomas. The authors investigated the mechanism of action of RU486 on uterine leiomyomas and myometrium, using prolactin production as a marker. Explant cultures using tissue from nine premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle were used, along with the immunohistochemical staining of tissue sections from five patients for P receptor (PR) subtype. Prolactin production was suppressed in both leiomyomas and myometrium after treatment with RU486 in vitro. This suppression may be a marker for the clinical effectiveness of agents used to treat leiomyomas.
|
|
pubmed:meshHeading |
pubmed-meshheading:8641483-Culture Media,
pubmed-meshheading:8641483-Estradiol,
pubmed-meshheading:8641483-Female,
pubmed-meshheading:8641483-Humans,
pubmed-meshheading:8641483-Hysterectomy,
pubmed-meshheading:8641483-Immunohistochemistry,
pubmed-meshheading:8641483-L-Lactate Dehydrogenase,
pubmed-meshheading:8641483-Leiomyoma,
pubmed-meshheading:8641483-Menstrual Cycle,
pubmed-meshheading:8641483-Mifepristone,
pubmed-meshheading:8641483-Myometrium,
pubmed-meshheading:8641483-Progesterone,
pubmed-meshheading:8641483-Prolactin,
pubmed-meshheading:8641483-Tumor Cells, Cultured
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
RU486 suppresses prolactin production in explant cultures of leiomyoma and myometrium.
|
|
pubmed:affiliation |
Department of Obstetrics, Gynecology, Harvard Medical School, Boston, Massachusetts, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
