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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-7-17
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pubmed:abstractText |
A ligand for the flt3 tyrosine kinase receptor (flt3R) has recently been cloned. Forty-three cases of childhood acute myeloid leukemia (AML) and 27 cases of childhood acute lymphocytic leukemia (ALL) were examined by flow cytometric analysis for cell-surface flt3R and proliferative response in vitro to flt3 ligand (flt3L). Flt3R was commonly expressed on the cell surface of leukemic cells from all AML subclasses and B-ALL, but we did not detect cell-surface flt3R on T-ALL. Flt3L alone induced the proliferation of the monocytic AML-M5 cells and some erythroleukemic AML-M6 cells. Some isolated instances of weak proliferative responses were also noted in other AML subclasses. Interleukin-4 (IL-4) alone inhibited the proliferation of a group of AML-M5 cells and, when combined with flt3L, suppressed the proliferative effect of flt3L. In general, B-ALL and T-ALL cells failed to respond to flt3L alone or in the presence of combinations of IL-2, IL-3, or IL-7.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
378-85
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8641369-Acute Disease,
pubmed-meshheading:8641369-Bone Marrow,
pubmed-meshheading:8641369-Burkitt Lymphoma,
pubmed-meshheading:8641369-Cell Division,
pubmed-meshheading:8641369-Child,
pubmed-meshheading:8641369-Cytokines,
pubmed-meshheading:8641369-Drug Synergism,
pubmed-meshheading:8641369-Gene Expression Regulation, Leukemic,
pubmed-meshheading:8641369-Hematopoietic Cell Growth Factors,
pubmed-meshheading:8641369-Humans,
pubmed-meshheading:8641369-Leukemia, Myeloid,
pubmed-meshheading:8641369-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:8641369-Membrane Proteins,
pubmed-meshheading:8641369-Neoplasm Proteins,
pubmed-meshheading:8641369-Neoplastic Stem Cells,
pubmed-meshheading:8641369-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:8641369-Proto-Oncogene Proteins,
pubmed-meshheading:8641369-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8641369-Tumor Cells, Cultured,
pubmed-meshheading:8641369-fms-Like Tyrosine Kinase 3
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pubmed:year |
1996
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pubmed:articleTitle |
Effects of flt3 ligand on acute myeloid and lymphocytic leukemic blast cells from children.
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pubmed:affiliation |
Immunex Research and Development Corp., Seattle, WA 98101, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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