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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-7-15
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pubmed:abstractText |
The mechanisms underlying cardiac contractile dysfunction after transplantation remain poorly defined. Previous work has revealed that inducible nitric oxide synthase (iNOS) is expressed in the rat heterotopic cardiac allograft during rejection; resultant overproduction of nitric oxide (NO) might cause cardiac contractile dysfunction via the negative inotropic and cytotoxic actions of NO. In this investigation, we tested the hypothesis that induction of iNOS may occur and be associated with cardiac allograft contractile dysfunction in humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-7322
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pubmed:author |
pubmed-author:BillinghamM EME,
pubmed-author:CookeJ PJP,
pubmed-author:FowlerM BMB,
pubmed-author:HaywoodG AGA,
pubmed-author:HuntS ASA,
pubmed-author:JohnsR ARA,
pubmed-author:LewisN PNP,
pubmed-author:RickenbacherP RPR,
pubmed-author:TrindadeP TPT,
pubmed-author:TsaiP YPY,
pubmed-author:ValantineH AHA,
pubmed-author:XueCC,
pubmed-author:von der LeyenHH
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
720-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8641001-Adolescent,
pubmed-meshheading:8641001-Adult,
pubmed-meshheading:8641001-Aged,
pubmed-meshheading:8641001-Animals,
pubmed-meshheading:8641001-Base Sequence,
pubmed-meshheading:8641001-DNA Primers,
pubmed-meshheading:8641001-Enzyme Induction,
pubmed-meshheading:8641001-Gene Expression,
pubmed-meshheading:8641001-Heart Transplantation,
pubmed-meshheading:8641001-Heart Ventricles,
pubmed-meshheading:8641001-Humans,
pubmed-meshheading:8641001-Middle Aged,
pubmed-meshheading:8641001-Molecular Sequence Data,
pubmed-meshheading:8641001-Myocardial Contraction,
pubmed-meshheading:8641001-Myocardium,
pubmed-meshheading:8641001-Nitric Oxide Synthase,
pubmed-meshheading:8641001-Polymerase Chain Reaction,
pubmed-meshheading:8641001-RNA, Messenger,
pubmed-meshheading:8641001-Rats
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pubmed:year |
1996
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pubmed:articleTitle |
Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle.
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pubmed:affiliation |
Division of Cardiovascular Medicine, Stanford (Calif) University School of Medicine, USA. nlewis@virginia.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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