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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1977-7-18
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pubmed:abstractText |
Antibodies to native DNA and to polyadenylic acid (Poly A) occur spontaneously and undergo a regulated switch from IgM to IgG during the course of autoimmune disease in NZB/NZW F(1) (B/W) mice. B/W females have higher titers and earlier commitment to 7S antibodies to DNA and Poly A, whereas B/W males bind DNA and Poly A primarily by 19S antibodies. We have performed castration experiments to determine the effects of sex hormones on this switch from IgM to IgG.NZB/NZW F(1) (B/W) mice were either castrated or subjected to sham surgery at 2 wk of age and studied for immunoglobulin class of antibodies to nucleic acids at 4, 6, and 7 mo post-surgery. Prepubertal castration of males caused premature death in 60% of mice. Castrated males had a significant decline in their serum testosterone concentration, an increase in DNA and Poly A binding, and an accelerated switch from 19S to 7S antibodies to nucleic acids. Castrated females had no change in mortality. However, castrated females given maintained androgen treatment had a decreased mortality compared to castrated females receiving estrogen (14 vs. 94%). The anticipated switch to 7S antibodies to Poly A was almost eliminated in castrated females. These results suggest that sex hormones modulate immunologic regulation and that androgenic hormones are protective in murine lupus.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1066-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:864003-Androgens,
pubmed-meshheading:864003-Animals,
pubmed-meshheading:864003-Autoantibodies,
pubmed-meshheading:864003-Castration,
pubmed-meshheading:864003-DNA,
pubmed-meshheading:864003-Drug Implants,
pubmed-meshheading:864003-Estrogens,
pubmed-meshheading:864003-Female,
pubmed-meshheading:864003-Gonadal Steroid Hormones,
pubmed-meshheading:864003-Immunity,
pubmed-meshheading:864003-Lupus Erythematosus, Systemic,
pubmed-meshheading:864003-Male,
pubmed-meshheading:864003-Mice,
pubmed-meshheading:864003-Poly A,
pubmed-meshheading:864003-Sex Factors,
pubmed-meshheading:864003-Testosterone
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pubmed:year |
1977
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pubmed:articleTitle |
Androgenic hormones modulate autoantibody responses and improve survival in murine lupus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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