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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-7-15
|
| pubmed:abstractText |
Large-cell variants are uncommon in mantle cell lymphoma (MCL). Here we describe the pathologic and clinical findings in five patients with large-cell lymphoma related to MCL (L-MCL), and compare them to a group of classic small-cell MCL (s-MCL) cases. Histologically, the MC origin of the large cells was evinced by their association with a small mantle cell component in the same tissue, or their distribution in a classic mantle zone pattern, or their development in a patient with previous s-MCL. The large cells were either pleomorphic mantle cells (case 1) or transformed blast-like cells (case 2-5). The median nuclear diameter, median nuclear area and proliferation index of L-MCLs and s-MCLs, were statistically different. Immunophenotypic characterization of four specimens of L-MCL and 10 of s-MCLs with a large panel of antibodies showed the classic findings of MCL, i.e. the IgM+ D+/-, CD5+, CD10-, CD23- phenotype in all cases except two (one CD5- and one CD23+), and the association with a loose follicular dendritic cell network. Two of four L-MCLs and 5/10 s-MCLs demonstrated rearrangements of the bcl-1 gene by Southern blot or by polymerase chain reaction (PCR); 2/4 L-MCLs and 1/9 s-MCLs had p53 mutations on single-strand conformation polymorphism analysis; none of the 14 specimens showed rearrangement of bcl-2 by PCR or bcl-6 and c-myc by Southern blot. All patients with 'transformed' histology (versus 37% of all others) died of lymphoma; their survival (15-18 months; median 17) was much shorter than that of all the others (28-117+ months; median 43) (P=0.0035). All three patients with p53 anomalies, two of whom had tumours with transformed histology, died of their disease in a short time (15, 18 and 28 months). In contrast, the presence of bcl-1 rearrangements did not have prognostic implications. This study documents the existence of large-cell variants of MCL and the poor prognosis associated with the 'transformed' cytologic type and/or p53 abnormalities.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
475-86
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8639452-Aged,
pubmed-meshheading:8639452-Base Sequence,
pubmed-meshheading:8639452-Blotting, Southern,
pubmed-meshheading:8639452-Cell Transformation, Neoplastic,
pubmed-meshheading:8639452-Female,
pubmed-meshheading:8639452-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:8639452-Humans,
pubmed-meshheading:8639452-Immunohistochemistry,
pubmed-meshheading:8639452-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:8639452-Lymphoma, Non-Hodgkin,
pubmed-meshheading:8639452-Male,
pubmed-meshheading:8639452-Middle Aged,
pubmed-meshheading:8639452-Molecular Sequence Data,
pubmed-meshheading:8639452-Neoplasm Staging,
pubmed-meshheading:8639452-Polymerase Chain Reaction,
pubmed-meshheading:8639452-Prognosis,
pubmed-meshheading:8639452-Retrospective Studies,
pubmed-meshheading:8639452-Tumor Suppressor Protein p53
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Large-cell variants of mantle cell lymphoma: cytologic characteristics and p53 anomalies may predict poor outcome.
|
| pubmed:affiliation |
Department of Pathology, Division of Hematopathology/Molecular Pathology, New York University Medical Center, NY, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|