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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5265
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pubmed:dateCreated |
1996-7-5
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pubmed:abstractText |
The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 180 seropositive men studied for more than 10 years. The risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects, including those with normal numbers of CD4+ T cells, was directly related to plasma viral load at study entry. Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4+ T cells.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
272
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1167-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8638160-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8638160-Antiviral Agents,
pubmed-meshheading:8638160-Biological Markers,
pubmed-meshheading:8638160-CD4 Lymphocyte Count,
pubmed-meshheading:8638160-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8638160-Cohort Studies,
pubmed-meshheading:8638160-Disease Progression,
pubmed-meshheading:8638160-Follow-Up Studies,
pubmed-meshheading:8638160-HIV Infections,
pubmed-meshheading:8638160-HIV-1,
pubmed-meshheading:8638160-Humans,
pubmed-meshheading:8638160-Male,
pubmed-meshheading:8638160-Prognosis,
pubmed-meshheading:8638160-Proportional Hazards Models,
pubmed-meshheading:8638160-RNA, Viral,
pubmed-meshheading:8638160-Survival Rate,
pubmed-meshheading:8638160-Time Factors,
pubmed-meshheading:8638160-Viremia,
pubmed-meshheading:8638160-Virus Replication
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pubmed:year |
1996
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pubmed:articleTitle |
Prognosis in HIV-1 infection predicted by the quantity of virus in plasma.
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pubmed:affiliation |
Department of Medicine, School of Medicine, University of Pittsburgh 15213, USA.
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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