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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5264
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pubmed:dateCreated |
1996-7-5
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pubmed:abstractText |
The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
272
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1008-10
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8638121-Amino Acid Sequence,
pubmed-meshheading:8638121-Animals,
pubmed-meshheading:8638121-Base Sequence,
pubmed-meshheading:8638121-Carrier Proteins,
pubmed-meshheading:8638121-Cell Line,
pubmed-meshheading:8638121-Cell Membrane,
pubmed-meshheading:8638121-Down-Regulation,
pubmed-meshheading:8638121-Endocytosis,
pubmed-meshheading:8638121-Epidermal Growth Factor,
pubmed-meshheading:8638121-HeLa Cells,
pubmed-meshheading:8638121-Humans,
pubmed-meshheading:8638121-Ligands,
pubmed-meshheading:8638121-Lysosomes,
pubmed-meshheading:8638121-Molecular Sequence Data,
pubmed-meshheading:8638121-Molecular Weight,
pubmed-meshheading:8638121-Receptor, Epidermal Growth Factor,
pubmed-meshheading:8638121-Transfection,
pubmed-meshheading:8638121-Vesicular Transport Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Enhanced degradation of EGF receptors by a sorting nexin, SNX1.
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pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla 92093-0650, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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