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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-7-10
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1279431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1312256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1312667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1327515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1372863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1384789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1417831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1550962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1592003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1630810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1631061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1710435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1711045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1717995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1791831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1924389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-1964089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-2045107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-2155144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-2158038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-2314296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-2479987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-2671254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7538139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7584949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7596435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7596436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7596437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7681362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7706320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7724599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7929268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-7958865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-8386825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8637916-8415706
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2576-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8637916-Amino Acid Sequence,
pubmed-meshheading:8637916-Animals,
pubmed-meshheading:8637916-Cells, Cultured,
pubmed-meshheading:8637916-Cloning, Molecular,
pubmed-meshheading:8637916-Endothelial Growth Factors,
pubmed-meshheading:8637916-Endothelium, Vascular,
pubmed-meshheading:8637916-Gene Expression Regulation,
pubmed-meshheading:8637916-Humans,
pubmed-meshheading:8637916-Mice,
pubmed-meshheading:8637916-Molecular Sequence Data,
pubmed-meshheading:8637916-Peptides,
pubmed-meshheading:8637916-RNA, Messenger,
pubmed-meshheading:8637916-Sequence Alignment,
pubmed-meshheading:8637916-Sequence Homology, Amino Acid,
pubmed-meshheading:8637916-Tissue Distribution,
pubmed-meshheading:8637916-Vascular Endothelial Growth Factor B
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pubmed:year |
1996
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pubmed:articleTitle |
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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