Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-7-5
|
| pubmed:abstractText |
Pulmonary chondroid hamartomas (PCH) are benign tumors of the lung characterized by a more or less high degree of mesenchymal metaplasia. In our series we investigated 30 PCH by a combination of cytogenetic and molecular methods. 18 tumors (60%) had cytogenetically detectable aberrations involving either 12q14-15 or 6p21 with a clear predominance of chromosomal abnormalities involving 12q14-15 (15 tumors). As in subgroups of pleomorphic adenomas of the salivary glands, leiomyomas of the uterus, and lipomas with 12q14-15 abnormalities the HMGI-C gene is frequently rearranged we tested PCH with either 12q14-15 abnormalities or normal karyotype by FISH and 3' RACE experiments for rearrangements of HMGI-C. Rearrangements were found in all cases with chromosomal 12q14-15 abnormalities and further six cases with an apparently normal karyotype. By the combination of cytogenetics with molecular techniques the percentage of cases with intragenic rearrangements of HMGI-C or rearrangements of its immediate surrounding was thus increased to 70% (21/30 cases). Considering all types of aberrations within this series 80% (24/30) of all PCH were aberrant. This is the first report on a combined molecular and cytogenetic analysis of a large series of pulmonary chondroid hamartomas indicating that rearrangements of HMGI-C, a member of the high mobility group protein gene family, are the leading molecular events in the genesis of PCH.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
515-21
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8637707-Adult,
pubmed-meshheading:8637707-Aged,
pubmed-meshheading:8637707-Base Sequence,
pubmed-meshheading:8637707-Chromosome Aberrations,
pubmed-meshheading:8637707-Chromosome Banding,
pubmed-meshheading:8637707-Chromosome Disorders,
pubmed-meshheading:8637707-Chromosome Mapping,
pubmed-meshheading:8637707-Chromosomes, Human, Pair 12,
pubmed-meshheading:8637707-DNA Primers,
pubmed-meshheading:8637707-Exons,
pubmed-meshheading:8637707-Female,
pubmed-meshheading:8637707-Gene Rearrangement,
pubmed-meshheading:8637707-HMGA2 Protein,
pubmed-meshheading:8637707-Hamartoma,
pubmed-meshheading:8637707-High Mobility Group Proteins,
pubmed-meshheading:8637707-Humans,
pubmed-meshheading:8637707-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8637707-Karyotyping,
pubmed-meshheading:8637707-Lung,
pubmed-meshheading:8637707-Male,
pubmed-meshheading:8637707-Middle Aged,
pubmed-meshheading:8637707-Molecular Sequence Data,
pubmed-meshheading:8637707-Phosphoproteins,
pubmed-meshheading:8637707-Polymerase Chain Reaction
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors.
|
| pubmed:affiliation |
Center for Human Genetics and Genetic Counselling, University of Bremen, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|