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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6583
|
| pubmed:dateCreated |
1996-7-9
|
| pubmed:abstractText |
The neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene that constitute, with Brn-3.0 (refs 1-3,8,9), the class IV POU-domain transcription factors. Brn-3.1 and Brn-3.2 provide a means of exploring the potentially distinct biological functions of expanded gene families in neural development. The highly related members of the Brn-3 family have similar DNA-binding preferences and overlapping expression patterns in the sensory nervous system, midbrain and hindbrain, suggesting functional redundancy. Here we report that Brn-3.1 and Brn-3.2 critically modulate the terminal differentiation of distinct sensorineural cells in which they exhibit selective spatial and temporal expression patterns. Deletion of the Brn-3.2 gene causes the loss of most retinal ganglion cells, defining distinct ganglion cell populations. Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pou4f2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor Brn-3B,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
381
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
603-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8637595-Animals,
pubmed-meshheading:8637595-Cell Differentiation,
pubmed-meshheading:8637595-DNA-Binding Proteins,
pubmed-meshheading:8637595-Deafness,
pubmed-meshheading:8637595-Ear, Inner,
pubmed-meshheading:8637595-Embryonic and Fetal Development,
pubmed-meshheading:8637595-Eye,
pubmed-meshheading:8637595-Gene Deletion,
pubmed-meshheading:8637595-Hair Cells, Auditory,
pubmed-meshheading:8637595-Homeodomain Proteins,
pubmed-meshheading:8637595-In Situ Hybridization,
pubmed-meshheading:8637595-Mice,
pubmed-meshheading:8637595-Multigene Family,
pubmed-meshheading:8637595-Retina,
pubmed-meshheading:8637595-Retinal Ganglion Cells,
pubmed-meshheading:8637595-Transcription Factor Brn-3B,
pubmed-meshheading:8637595-Transcription Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.
|
| pubmed:affiliation |
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|