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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1996-7-10
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pubmed:abstractText |
The rate of insulin-stimulated glucose disposal is reduced in individuals with insulin resistance, and is associated with a blunted or absent increase in energy expenditure in response to a glucose load. The magnitude of the effect of glucose on energy expenditure (EGEE) may be a function of opposing changes in the rate of glucose disposal (Rd) and hepatic glucose production (HGP). In this study, six women with non-insulin-dependent diabetes mellitus (NIDDM) were studied on a metabolic ward in each of three conditions. On days 1 and 2, they did no exercise (NX) or else performed low-intensity exercise ([LO] 3,118 kJ [745 kcal]) at 50% maximal oxygen consumption [V0(2)max]) or high-intensity exercise ([HI] 3,114 kJ [744 kcal] at 75% V0(2)max). On day 3, infusion of 6,6(2)H-glucose in the basal state was immediately followed by infusion of glucose, 6,6(2)H-glucose, and insulin at fixed rates. Indirect calorimetry was performed during the last 30 minutes of each infusion. EGEE was not different among the three conditions (mean +/- SEM: NX -0.18 +/- 0.11, LO -0.08 +/- 0.05, and HI -0.08 +/- 0.07 kJ/min) and was inversely related to steady-state plasma glucose concentration, a direct measure of insulin resistance (r = -.89, P < .05). EGEE was positively correlated with glucose Rd (r = .94, P < .001) and negatively correlated with HGP (r = -.91, P < .05). The data indicate that the glucose effect on energy expenditure was slightly positive in the more insulin-sensitive individuals, but negative in the more insulin-resistant subjects. The EGEE appears to be determined by the relative balance between energy required to store glucose and energy saved by suppression of glucose production.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0026-0495
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
747-52
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8637450-Body Temperature Regulation,
pubmed-meshheading:8637450-Calorimetry,
pubmed-meshheading:8637450-Diabetes Mellitus, Type 2,
pubmed-meshheading:8637450-Energy Metabolism,
pubmed-meshheading:8637450-Exercise,
pubmed-meshheading:8637450-Female,
pubmed-meshheading:8637450-Glucose,
pubmed-meshheading:8637450-Humans,
pubmed-meshheading:8637450-Insulin Resistance,
pubmed-meshheading:8637450-Obesity
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pubmed:year |
1996
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pubmed:articleTitle |
Relationships between glucose metabolism and thermogenesis with and without prior exercise in obese women with non-insulin-dependent diabetes mellitus.
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pubmed:affiliation |
Department of Nutritional Sciences, University of California at Berkeley, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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