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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-7-5
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pubmed:abstractText |
Interleukin-2 (IL-2) plays a pivotal role in the cellular and humoral immune responses directed against foreign antigens. We characterized the in vitro and in vivo properties of a chimeric protein consisting of mouse IL-2 fused to the mouse IgG2b Fc domains. This fusion protein binds to IL-2 and Fc receptors and supports IL-2-dependent cell proliferation but does not mediate lysis of IL-2 receptor-positive cells in the presence of murine complement in vitro. However, in vivo the IL2-IgG2b fusion protein suppresses both cellular and humoral immune responses after immunization with sheep erythrocytes. Surprisingly, delayed hypersensitivity is inhibited despite a dramatic increase of splenic CD3+ and NK1.1+ lymphocytes, indicating that altered homing of IL2-IgG2b-activated lymphocytes rather than cytolysis prevents these cells from accumulating in areas of inflammation. Although in vitro the IL2-IgG2b fusion protein does not alter proliferation of B cells in response to mitogenic stimulation, IgM production in response to sheep erythrocytes is profoundly inhibited in mice treated with the IL2-IgG2b fusion protein. Since no side effects are observed, the IL2-IgG2b fusion protein may expand the therapeutic repertoire of reagents used for the treatment of allograft rejection and autoimmune diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1323143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1454817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1496399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1858138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1944559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1970124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-1988502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-2157982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-2437578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-2474211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-3091483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-3279578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-3501369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-6198355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-6206144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-6401302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-6425405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-7520604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-7526493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-767254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-7681469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-7716523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-7833625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-7940738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-8077661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8636431-8464888
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1204-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8636431-Animals,
pubmed-meshheading:8636431-Antibody Formation,
pubmed-meshheading:8636431-Female,
pubmed-meshheading:8636431-Hypersensitivity, Delayed,
pubmed-meshheading:8636431-Immunoglobulin G,
pubmed-meshheading:8636431-Immunosuppressive Agents,
pubmed-meshheading:8636431-Interleukin-2,
pubmed-meshheading:8636431-Lymphocyte Activation,
pubmed-meshheading:8636431-Mice,
pubmed-meshheading:8636431-Mice, Inbred C57BL,
pubmed-meshheading:8636431-Recombinant Fusion Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunoglobulin fusion protein in mice.
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pubmed:affiliation |
Institute of Immunology, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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